Detailed information of TA system TA037660

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 2887596..2888086
• Replicon: chromosome
• Accession: NZ_AP023358
• Organism: Micromonospora endophytica strain NBRC 109090

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: Jiend_RS13650
• Protein ID: WP_111245626.1
• Coordinates: 2887832..2888086 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: Jiend_RS13645
• Protein ID: WP_249412393.1
• Coordinates: 2887596..2887835 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Jiend_RS13640 (Jiend_28280)	2886462..2887424	-	963	WP_111245628.1	L-threonylcarbamoyladenylate synthase	-
Jiend_RS13645 (Jiend_28290)	2887596..2887835	+	240	WP_249412393.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
Jiend_RS13650 (Jiend_28300)	2887832..2888086	+	255	WP_111245626.1	Txe/YoeB family addiction module toxin	Toxin
Jiend_RS13660 (Jiend_28310)	2888250..2888378	-	129	WP_212808688.1	DLW-39 family protein	-
Jiend_RS13670 (Jiend_28320)	2888689..2889615	-	927	WP_119663719.1	DUF3566 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-57)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10201.47 Da
• Isoelectric Point: 9.9423

>T37660 WP_111245626.1 NZ_AP023358:2887832-2888086 [Micromonospora endophytica]
VKIQFASRGWEDYLAWQRDRQMLKRVNALIEDIRRNGHQGIGKPEQLRGNWAGFWSRRIDQEHRLGYRITDDTVQIAQCR
YHYE

Nucleotide

• Length: 255 bp

>T37660 NZ_AP023358:2887832-2888086 [Micromonospora endophytica]
GTGAAGATCCAGTTCGCCAGCCGAGGCTGGGAAGACTACCTGGCCTGGCAACGAGATCGTCAGATGCTCAAACGAGTGAA
CGCCTTGATCGAGGACATCCGACGCAACGGCCATCAAGGCATCGGCAAACCGGAGCAGCTCCGCGGCAACTGGGCGGGAT
TCTGGTCGAGGCGCATCGACCAGGAACACCGTCTCGGGTACCGGATCACTGACGACACAGTGCAGATCGCGCAGTGCCGC
TACCACTACGAATAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8456.30 Da
• Isoelectric Point: 4.0940

>AT37660 WP_249412393.1 NZ_AP023358:2887596-2887835 [Micromonospora endophytica]
MLDHVVDDAEEVVVTRSGREAAVIISLREYESLKETAYLMASPANARRLNEAVDELRNGGGEMHDLIDPDAGSGEASAA

Nucleotide

• Length: 240 bp

>AT37660 NZ_AP023358:2887596-2887835 [Micromonospora endophytica]
ATGCTCGACCATGTCGTGGACGACGCCGAGGAAGTGGTGGTCACCCGCTCCGGCCGGGAGGCCGCAGTCATCATCTCGCT
GCGCGAGTACGAGTCGTTGAAGGAGACGGCCTACCTGATGGCCAGCCCCGCCAACGCGCGCCGCCTGAATGAGGCCGTCG
ACGAGCTGCGCAACGGGGGTGGGGAGATGCACGACCTGATCGATCCCGATGCCGGTTCAGGCGAGGCGTCGGCAGCGTGA