Detailed information of TA system TA037659

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PHD(antitoxin)
• Location: 2663517..2664202
• Replicon: chromosome
• Accession: NZ_AP023358
• Organism: Micromonospora endophytica strain NBRC 109090

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: Jiend_RS12540
• Protein ID: WP_111242141.1
• Coordinates: 2663517..2663927 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: Jiend_RS12545
• Protein ID: WP_111242142.1
• Coordinates: 2663924..2664202 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Jiend_RS12520 (Jiend_25960)	2659670..2660338	-	669	WP_111242137.1	response regulator transcription factor	-
Jiend_RS12525 (Jiend_25970)	2660370..2661959	-	1590	WP_111242138.1	histidine kinase	-
Jiend_RS12530 (Jiend_25980)	2661971..2662873	-	903	WP_181445022.1	CPBP family intramembrane metalloprotease	-
Jiend_RS12535 (Jiend_25990)	2663050..2663418	+	369	WP_111242140.1	hypothetical protein	-
Jiend_RS12540 (Jiend_26000)	2663517..2663927	-	411	WP_111242141.1	type II toxin-antitoxin system VapC family toxin	Toxin
Jiend_RS12545 (Jiend_26010)	2663924..2664202	-	279	WP_111242142.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
Jiend_RS12550 (Jiend_26020)	2664275..2666067	-	1793	Protein_2516	ABC transporter ATP-binding protein	-
Jiend_RS12555 (Jiend_26040)	2666153..2666593	+	441	WP_111242144.1	MarR family transcriptional regulator	-
Jiend_RS12560 (Jiend_26050)	2666680..2666925	+	246	WP_212808676.1	hypothetical protein	-
Jiend_RS12565 (Jiend_26060)	2667165..2667824	+	660	WP_181445023.1	YbaB/EbfC family nucleoid-associated protein	-
Jiend_RS12570 (Jiend_26070)	2667826..2668158	+	333	WP_111242147.1	hypothetical protein	-
Jiend_RS12575 (Jiend_26080)	2668186..2668956	+	771	WP_111242148.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-50)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14368.51 Da
• Isoelectric Point: 5.1356

>T37659 WP_111242141.1 NZ_AP023358:c2663927-2663517 [Micromonospora endophytica]
VIYLDSAAVVKLVRQEECSADLVAWLNSHDDVPLVSSALVEVEVPRALRRSAPQALIGVPAAVGRLFRLEIDSTIRATAA
AFAEPALRSLDAIHLATAQVLTNESGTALVAFVSYDRRLLEQAKIAGLPVASPGQG

Nucleotide

• Length: 411 bp

>T37659 NZ_AP023358:c2663927-2663517 [Micromonospora endophytica]
GTGATCTACCTCGATTCCGCTGCCGTCGTCAAGCTGGTGCGGCAGGAGGAATGCAGCGCTGACCTCGTCGCCTGGCTGAA
CAGTCACGACGACGTACCGCTGGTCTCCTCCGCCCTGGTCGAGGTGGAAGTGCCCCGAGCGTTACGACGCTCCGCTCCGC
AAGCCCTGATCGGAGTGCCGGCCGCTGTCGGCCGGCTCTTCCGGCTGGAGATCGACAGCACGATCCGCGCGACCGCAGCG
GCCTTCGCCGAGCCGGCGCTCCGTAGTCTCGACGCCATCCACCTGGCCACCGCACAGGTGCTGACCAACGAGTCCGGTAC
GGCACTTGTCGCCTTCGTCAGCTATGACCGGCGACTGCTCGAACAGGCCAAGATCGCGGGACTGCCCGTCGCGAGTCCCG
GCCAGGGCTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 9812.27 Da
• Isoelectric Point: 6.3304

>AT37659 WP_111242142.1 NZ_AP023358:c2664202-2663924 [Micromonospora endophytica]
MERIGVRELNQNTSQVLARVSGGETVEITDRGRLIARLVPVGDDRSMLARLVAAGRAVAPIGGGPVPLPPKLGDENVNVA
ATLAAMREEERW

Nucleotide

• Length: 279 bp

>AT37659 NZ_AP023358:c2664202-2663924 [Micromonospora endophytica]
ATGGAGCGCATCGGGGTGCGGGAGCTGAACCAGAACACCAGCCAGGTGCTGGCGCGGGTGAGTGGCGGTGAGACCGTCGA
GATCACCGACCGTGGGCGGCTGATCGCCCGACTTGTCCCGGTAGGTGACGACAGGTCAATGTTGGCCAGGTTGGTCGCCG
CCGGACGGGCGGTCGCTCCGATCGGCGGCGGCCCTGTTCCGCTTCCGCCGAAGCTCGGTGACGAGAACGTGAACGTGGCC
GCCACCCTCGCCGCAATGCGGGAGGAGGAGCGCTGGTGA