Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 2639612..2640141 Replicon chromosome
Accession NZ_AP023358
Organism Micromonospora endophytica strain NBRC 109090

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag Jiend_RS12395 Protein ID WP_111242115.1
Coordinates 2639884..2640141 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag Jiend_RS12390 Protein ID WP_111242155.1
Coordinates 2639612..2639887 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Jiend_RS12380 (Jiend_25710) 2638752..2639234 - 483 WP_223256755.1 DUF1772 domain-containing protein -
Jiend_RS12390 (Jiend_25720) 2639612..2639887 + 276 WP_111242155.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
Jiend_RS12395 (Jiend_25730) 2639884..2640141 + 258 WP_111242115.1 Txe/YoeB family addiction module toxin Toxin
Jiend_RS12400 (Jiend_25740) 2640369..2640722 - 354 WP_111242116.1 hypothetical protein -
Jiend_RS12405 (Jiend_25750) 2640719..2641186 - 468 WP_223256752.1 hypothetical protein -
Jiend_RS32095 2641217..2641339 + 123 WP_258378263.1 hypothetical protein -
Jiend_RS12410 (Jiend_25760) 2641656..2642048 + 393 WP_111242117.1 hypothetical protein -
Jiend_RS12415 (Jiend_25770) 2642045..2642575 + 531 WP_111242118.1 DUF6036 family nucleotidyltransferase -
Jiend_RS12420 (Jiend_25780) 2642616..2643029 - 414 WP_111242119.1 XRE family transcriptional regulator -
Jiend_RS12425 (Jiend_25790) 2643278..2643685 - 408 WP_249412385.1 hypothetical protein -
Jiend_RS12430 (Jiend_25800) 2643777..2644928 - 1152 WP_111242121.1 helix-turn-helix domain-containing protein -
Jiend_RS12435 2644925..2645071 - 147 WP_181445021.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-82)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10093.53 Da        Isoelectric Point: 9.7992

>T37658 WP_111242115.1 NZ_AP023358:2639884-2640141 [Micromonospora endophytica]
VRLVFTATAWSQYLSHTDRKLVKRINDLIADVMRNGYEGIGKPEPLRGELSGFWSRRIDREHRLVYRITKDDVEIIACRY
HYGDR

Download         Length: 258 bp

>T37658 NZ_AP023358:2639884-2640141 [Micromonospora endophytica]
GTGAGGCTGGTCTTCACCGCGACAGCATGGAGCCAGTACCTCAGCCACACCGACCGCAAGCTGGTCAAGCGCATCAACGA
TCTCATCGCCGATGTGATGCGCAACGGGTACGAGGGCATCGGAAAGCCGGAGCCCTTGCGGGGCGAGCTGTCCGGCTTCT
GGTCCCGCCGGATCGACCGCGAACACCGGCTGGTGTACCGAATCACCAAGGACGACGTCGAAATCATCGCCTGCCGATAC
CACTACGGCGACCGGTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10133.22 Da        Isoelectric Point: 4.0950

>AT37658 WP_111242155.1 NZ_AP023358:2639612-2639887 [Micromonospora endophytica]
MRTVNFTQLRQNLAAELDSVIDDAEEVVVTRSGHEPVVIVSLAEYESMKETEYLLRSPSNAAVLRRSIAELEQGDTTERE
LADPDTARDVA

Download         Length: 276 bp

>AT37658 NZ_AP023358:2639612-2639887 [Micromonospora endophytica]
ATGCGGACCGTGAACTTCACCCAGCTACGCCAGAACCTGGCTGCCGAACTCGACAGCGTCATCGACGACGCCGAGGAAGT
GGTGGTGACCCGCTCGGGCCATGAGCCGGTGGTGATCGTGTCGCTGGCCGAGTACGAGTCGATGAAGGAAACCGAGTACC
TCCTGCGTAGCCCCAGCAACGCCGCAGTCCTTCGCCGGTCGATCGCCGAGCTTGAGCAGGGCGACACGACCGAGCGGGAG
CTGGCCGACCCGGACACCGCGCGAGACGTCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References