Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5846187..5846809 Replicon chromosome
Accession NZ_AP023348
Organism Pseudomonas sp. RtIB026

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PRtIB026_RS26325 Protein ID WP_050703388.1
Coordinates 5846618..5846809 (-) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PRtIB026_RS26320 Protein ID WP_203648640.1
Coordinates 5846187..5846600 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PRtIB026_RS26290 5842069..5842767 + 699 WP_203648630.1 HNH endonuclease -
PRtIB026_RS26295 5842769..5843167 + 399 WP_203648632.1 hypothetical protein -
PRtIB026_RS26300 5843863..5845008 + 1146 WP_203648634.1 nitrite reductase, copper-containing -
PRtIB026_RS26305 5845086..5845298 + 213 WP_203648636.1 DUF3079 domain-containing protein -
PRtIB026_RS26310 5845378..5845626 + 249 WP_203648638.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
PRtIB026_RS26315 5845637..5845984 + 348 WP_186712059.1 type II toxin-antitoxin system RelE/ParE family toxin -
PRtIB026_RS26320 5846187..5846600 - 414 WP_203648640.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PRtIB026_RS26325 5846618..5846809 - 192 WP_050703388.1 type II toxin-antitoxin system HicA family toxin Toxin
PRtIB026_RS26330 5847339..5848364 - 1026 WP_203646634.1 IS110 family transposase -
PRtIB026_RS26335 5848694..5849239 - 546 WP_203648642.1 HDIG domain-containing protein -
PRtIB026_RS26340 5849312..5850367 - 1056 WP_203648644.1 haloacid dehalogenase-like hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5839723..5848364 8641


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7045.16 Da        Isoelectric Point: 10.4613

>T37653 WP_050703388.1 NZ_AP023348:c5846809-5846618 [Pseudomonas sp. RtIB026]
MNSREMISVIEADGWYLVRSKGSHHHFKHPEKPGLVTIPHPKKDLLPATAASILRQARIGYAS

Download         Length: 192 bp

>T37653 NZ_AP023348:c5846809-5846618 [Pseudomonas sp. RtIB026]
ATGAACAGCCGTGAAATGATTTCAGTGATCGAGGCGGATGGCTGGTATCTGGTGCGTTCGAAAGGCAGCCACCATCACTT
CAAGCATCCCGAAAAGCCAGGCCTGGTCACCATCCCGCACCCAAAGAAAGACCTGCTGCCGGCCACTGCGGCCAGCATCC
TGCGCCAGGCGCGGATCGGCTATGCCAGTTGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 14964.06 Da        Isoelectric Point: 4.5901

>AT37653 WP_203648640.1 NZ_AP023348:c5846600-5846187 [Pseudomonas sp. RtIB026]
MLFPIAILPGDDQHAWGVEVPDIPGCFSAGEDLDNAIAMAREAIEGHLELLAQEQQEIPKASLVSVHAANPSYAGCTWAL
IDIDITRYLGKAEKLNITLPAYLLTRIDSYVQNHPEHKSRSGFLAEAALRILQGDCK

Download         Length: 414 bp

>AT37653 NZ_AP023348:c5846600-5846187 [Pseudomonas sp. RtIB026]
ATGTTGTTCCCCATTGCGATTCTCCCCGGTGACGATCAACACGCCTGGGGTGTTGAAGTCCCTGACATCCCGGGCTGTTT
CTCGGCCGGCGAAGACCTCGACAACGCCATCGCCATGGCCCGCGAAGCCATCGAAGGCCACCTCGAACTGCTGGCCCAGG
AGCAGCAGGAGATCCCCAAGGCCAGCCTGGTCAGCGTACACGCAGCCAATCCGTCCTATGCCGGTTGTACCTGGGCGCTG
ATCGATATAGACATCACCCGTTACCTGGGCAAGGCCGAGAAGCTCAACATCACACTGCCGGCGTACCTGCTCACCCGCAT
CGATTCGTATGTGCAGAACCACCCGGAGCACAAGAGTCGCTCGGGTTTCCTGGCCGAGGCGGCGCTGAGGATTTTGCAGG
GTGATTGCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References