Detailed information of TA system TA037645

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 17850..19059
• Replicon: chromosome
• Accession: NZ_AP023347
• Organism: Helicobacter pylori strain JSHR6

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: M2Y46_RS00070
• Protein ID: WP_171931441.1
• Coordinates: 18277..19059 (+)
• Length: 261 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: M2Y46_RS00065
• Protein ID: WP_212877837.1
• Coordinates: 17850..18287 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2Y46_RS00060 (JSHR6_00120)	16077..17624	+	1548	WP_248415401.1	RNA-directed DNA polymerase	-
M2Y46_RS00065 (JSHR6_00130)	17850..18287	+	438	WP_212877837.1	Panacea domain-containing protein	Antitoxin
M2Y46_RS00070 (JSHR6_00140)	18277..19059	+	783	WP_171931441.1	hypothetical protein	Toxin
M2Y46_RS00075 (JSHR6_00150)	19286..20473	-	1188	WP_248415402.1	transcription termination factor NusA	-
M2Y46_RS00080 (JSHR6_00160)	20561..21721	-	1161	WP_248415403.1	aminotransferase class V-fold PLP-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 261 a.a.
• Molecular weight: 30637.84 Da
• Isoelectric Point: 9.5822

>T37645 WP_171931441.1 NZ_AP023347:18277-19059 [Helicobacter pylori]
METKEEDKDKKLEKIIVLLCEEGDLSSQKDQIIKDLKEIYKGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIRLEDDLNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSKEKKDKQENFFKKPIFWFNLMVTILFVIGFV
GERIDRQYKAQISKDFKRPR

Nucleotide

• Length: 783 bp

>T37645 NZ_AP023347:18277-19059 [Helicobacter pylori]
ATGGAAACTAAAGAAGAGGATAAAGATAAAAAGCTAGAAAAAATTATTGTATTGTTGTGCGAAGAGGGGGATTTGTCTAG
CCAAAAAGATCAAATCATCAAAGATCTCAAAGAAATCTATAAAGGAGAATACAAGCATAAATACTCAAAAATCACAACTA
TTATTTTAAATTCCACAAGGGATAAAGAGCAAGCCTTTATGATGCTCACACAAAATATAAAGACACTCAAAGAGATTCAA
GATAATAAGGAAGTTGAAAGCATTAAGCCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTATCAGGTTAGAAGATGATCTAAATAAAAACTATAAAAAAT
TAAGCGAAGAATTGAATAAGCAGCAAACGCAATACATAACAATTTTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTT
GGGGGATTGGCGTTTTCTACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGTTTGGTTTTTGTTATGGCTTT
TATAGCTTTATTTTTTGGGAATATTTTATATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCAAAAGAGAAAAAAG
ATAAACAAGAAAATTTTTTCAAAAAACCTATTTTTTGGTTTAATCTGATGGTTACAATCCTATTTGTGATTGGTTTTGTG
GGAGAGAGAATTGATAGGCAATATAAAGCTCAGATTTCTAAAGATTTTAAAAGACCAAGATAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17221.37 Da
• Isoelectric Point: 6.2627

>AT37645 WP_212877837.1 NZ_AP023347:17850-18287 [Helicobacter pylori]
MVNALELAKYILKRSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLRKDELETINCSIEKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEVISKDLIKQEAKQANGN

Nucleotide

• Length: 438 bp

>AT37645 NZ_AP023347:17850-18287 [Helicobacter pylori]
ATGGTCAATGCTTTGGAACTAGCAAAATATATTCTTAAGCGTTCAAACAAAGAATTGAGCAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATCAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAAATATG
GGCCTGTTGCAAGGGAAGTGTATTATGAATATCGCAATTATGGTGCCAATTCCATTGACAAACCCAAAGAAGAAACGCTC
TCACAAAATCTTAGAAAAGATGAATTGGAAACCATCAATTGCTCCATAGAAAAATGCAACGAAAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAGGAAGATGGTGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAGTCATTAGCAAAGATT
TGATCAAACAAGAAGCAAAACAAGCAAATGGAAACTAA