Detailed information of TA system TA037644

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 578024..578588
• Replicon: chromosome
• Accession: NZ_AP023345
• Organism: Helicobacter pylori strain JSHR31

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: M2Y57_RS02795
• Protein ID: WP_248426358.1
• Coordinates: 578322..578588 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: X2IKC6
• Locus tag: M2Y57_RS02790
• Protein ID: WP_001133858.1
• Coordinates: 578024..578335 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2Y57_RS02765 (JSHR31_05380)	573750..574367	-	618	WP_248426355.1	helicase DnaB modulator	-
M2Y57_RS02780 (JSHR31_05390)	574778..577009	+	2232	WP_248426356.1	outer membrane beta-barrel protein	-
M2Y57_RS02785 (JSHR31_05400)	577607..577948	+	342	WP_248426357.1	hypothetical protein	-
M2Y57_RS02790 (JSHR31_05410)	578024..578335	+	312	WP_001133858.1	type II toxin-antitoxin system antitoxin	Antitoxin
M2Y57_RS02795 (JSHR31_05420)	578322..578588	+	267	WP_248426358.1	type II toxin-antitoxin system YafQ family toxin	Toxin
M2Y57_RS02800 (JSHR31_05430)	578696..579220	-	525	WP_001135602.1	acyl-CoA thioesterase	-
M2Y57_RS02805 (JSHR31_05440)	579359..580201	+	843	WP_248426359.1	SDR family oxidoreductase	-
M2Y57_RS02810 (JSHR31_05450)	580194..581174	+	981	WP_000921458.1	iron chelate uptake ABC transporter family permease subunit	-
M2Y57_RS02815 (JSHR31_05460)	581174..581941	+	768	WP_000242366.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10281.28 Da
• Isoelectric Point: 8.8871

>T37644 WP_248426358.1 NZ_AP023345:578322-578588 [Helicobacter pylori]
MLMIETSKKFDKDLKILVKNGFDLKLLYKVVENLAKEQPLAPKYKDHPLKGTLKDFRECHIKPDILLVYLVKDDELILVR
LGSHSELF

Nucleotide

• Length: 267 bp

>T37644 NZ_AP023345:578322-578588 [Helicobacter pylori]
ATGCTGATGATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAACGGGTTTGATTTGAAGCTTTT
ATATAAAGTGGTTGAAAATTTAGCCAAAGAGCAACCCCTAGCTCCCAAATACAAAGACCATCCGCTCAAAGGCACTTTAA
AAGATTTTAGGGAATGCCACATTAAACCTGATATTTTGCTTGTGTATCTAGTGAAAGATGATGAGCTTATTTTAGTAAGA
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 12290.11 Da
• Isoelectric Point: 10.1678

>AT37644 WP_001133858.1 NZ_AP023345:578024-578335 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNH
LCFKSVEDFKKHCENLRFKNADD

Nucleotide

• Length: 312 bp

>AT37644 NZ_AP023345:578024-578335 [Helicobacter pylori]
ATGCCTAACTCTCCCACCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTAACTTTTTAAATTCTATTAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAAGAAATCCAAGCTCAAAAACAAAGAATCAAAAAAGCGCTCCAATTTAAAG
CGCTCCATTTAACCGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGACACCAAGAACCAC
CTTTGTTTTAAAAGCGTAGAGGATTTTAAAAAGCATTGTGAAAACTTAAGATTTAAAAATGCTGATGATTGA

Structures

Antitoxin

• AlphaFold DB: X2IKC6