37643

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 1113062..1113647 Replicon chromosome
Accession NZ_AP023344
Organism Helicobacter pylori strain JSHR3

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag M2Y48_RS05320 Protein ID WP_248419704.1
Coordinates 1113062..1113349 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag M2Y48_RS05325 Protein ID WP_248419705.1
Coordinates 1113336..1113647 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2Y48_RS05300 (JSHR3_10910) 1109722..1110489 - 768 WP_248419699.1 ABC transporter ATP-binding protein -
M2Y48_RS05305 (JSHR3_10920) 1110489..1111469 - 981 WP_248419701.1 iron ABC transporter permease -
M2Y48_RS05310 (JSHR3_10930) 1111462..1112310 - 849 WP_096529639.1 SDR family oxidoreductase -
M2Y48_RS05315 (JSHR3_10940) 1112451..1112975 + 525 WP_220899756.1 acyl-CoA thioesterase -
M2Y48_RS05320 (JSHR3_10950) 1113062..1113349 - 288 WP_248419704.1 type II toxin-antitoxin system YafQ family toxin Toxin
M2Y48_RS05325 (JSHR3_10960) 1113336..1113647 - 312 WP_248419705.1 type II toxin-antitoxin system antitoxin Antitoxin
M2Y48_RS05330 (JSHR3_10970) 1114053..1116269 - 2217 WP_248419707.1 outer membrane beta-barrel protein -
M2Y48_RS05345 (JSHR3_10980) 1116640..1117276 + 637 Protein_1056 helicase DnaB modulator -
M2Y48_RS05350 (JSHR3_10990) 1117227..1118339 - 1113 WP_248419709.1 hydrogenase formation protein HypD -
M2Y48_RS05355 (JSHR3_11000) 1118358..1118594 - 237 WP_000335472.1 HypC/HybG/HupF family hydrogenase formation chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11071.04 Da        Isoelectric Point: 8.0871

>T37643 WP_248419704.1 NZ_AP023344:c1113349-1113062 [Helicobacter pylori]
MLMIETSKKFDKDLKILVKNGFDLKLLYKVVENLAKEQPLDPKYKDHPLKGTLKDFRECHIKSDTLLVYLVQGDELILVR
LGSHSELFLNHPHNL

Download         Length: 288 bp

>T37643 NZ_AP023344:c1113349-1113062 [Helicobacter pylori]
ATGCTGATGATTGAAACCAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAACGGGTTTGATTTAAAGCTTTT
ATATAAAGTGGTTGAAAATTTAGCCAAAGAGCAACCCCTAGATCCCAAATACAAAGACCACCCGCTCAAAGGCACTTTAA
AAGATTTTAGGGAATGCCACATCAAATCTGATACTTTGCTTGTGTATTTAGTGCAAGGTGATGAGCTTATTTTAGTAAGA
CTAGGCAGTCATAGCGAGCTGTTTTTAAACCACCCGCACAACTTATAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 12365.22 Da        Isoelectric Point: 10.1673

>AT37643 WP_248419705.1 NZ_AP023344:c1113647-1113336 [Helicobacter pylori]
MPNSPIKKDYTRYSEKQLFNFLDSIKTKQKRALEKLKEIQAQKQRIKKALQFKAFHLTENGYTIEEEREILARAKDTKNH
LCFKSVEDFKKHCENLRFKNADD

Download         Length: 312 bp

>AT37643 NZ_AP023344:c1113647-1113336 [Helicobacter pylori]
ATGCCTAACTCTCCCATCAAAAAAGACTACACACGATACAGCGAAAAACAGCTTTTTAACTTTTTAGATTCTATTAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAAGAAATCCAAGCTCAAAAACAAAGAATCAAAAAAGCCCTCCAATTTAAAG
CGTTCCATTTAACCGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGACACCAAGAACCAC
CTTTGTTTTAAAAGCGTAGAGGATTTTAAAAAGCATTGTGAAAACTTAAGATTTAAAAATGCTGATGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References