37637

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 210477..210999 Replicon plasmid pMH15-269M_1
Accession NZ_AP023338
Organism Klebsiella pneumoniae strain MH15-269M

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag HRS02_RS26645 Protein ID WP_004181778.1
Coordinates 210715..210999 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag HRS02_RS26640 Protein ID WP_004181777.1
Coordinates 210477..210725 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRS02_RS26620 205686..206507 - 822 WP_004181772.1 hypothetical protein -
HRS02_RS26625 206569..206922 - 354 WP_004181774.1 hypothetical protein -
HRS02_RS26630 207067..208053 - 987 WP_094965947.1 hypothetical protein -
HRS02_RS26635 208387..210186 - 1800 WP_004181776.1 ATP-dependent helicase -
HRS02_RS26640 210477..210725 + 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HRS02_RS26645 210715..210999 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRS02_RS26650 211016..211117 - 102 Protein_226 IS200/IS605 family transposase -
HRS02_RS26655 211153..212379 + 1227 WP_040209639.1 transposase -
HRS02_RS26660 212650..212874 - 225 Protein_228 transposase -
HRS02_RS26665 212953..213381 - 429 WP_077257669.1 IS200/IS605 family transposase -
HRS02_RS26670 213417..214604 + 1188 WP_040209642.1 transposase -
HRS02_RS26675 214703..215798 - 1096 Protein_231 conjugal transfer protein TraG N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aadA2 / cmlA1 / ant(3'')-Ia / sul3 / aac(3)-IVa / aph(4)-Ia / aph(6)-Id / aph(3'')-Ib / mph(E) / msr(E) / armA / sul1 / blaDHA-1 / qnrB4 - 1..288040 288040


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T37637 WP_004181778.1 NZ_AP023338:210715-210999 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

>T37637 NZ_AP023338:210715-210999 [Klebsiella pneumoniae]
ATGACTTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTCGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTACATGGACGCAAAGACCAATACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTGACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACAATTTAACCAAACACAGAAATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT37637 WP_004181777.1 NZ_AP023338:210477-210725 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp

>AT37637 NZ_AP023338:210477-210725 [Klebsiella pneumoniae]
ATGGCATTTCAGGTACTAACCACTACTGCAGCAAGCATCACAGAGCTTAAACGTGATCCTATGGGCACTTTCAATGCAGG
AGAAGGTGCCCCTGTAGCCATACTGAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTCTTGAAGATCAGGAGCTGGGTCGTATTGCTGATGAGCGAATTGGTGAGGCGGTAATCGAGGTCAGTCTAGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References