Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4687173..4687689 Replicon chromosome
Accession NZ_AP023337
Organism Klebsiella pneumoniae strain MH15-269M

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag HRS02_RS22775 Protein ID WP_009486548.1
Coordinates 4687173..4687457 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HRS02_RS22780 Protein ID WP_002886901.1
Coordinates 4687447..4687689 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRS02_RS22750 4682590..4682898 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
HRS02_RS22755 4682983..4683156 + 174 WP_032433782.1 hypothetical protein -
HRS02_RS22760 4683159..4683902 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HRS02_RS22765 4684259..4686397 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HRS02_RS22770 4686705..4687169 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HRS02_RS22775 4687173..4687457 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRS02_RS22780 4687447..4687689 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HRS02_RS22785 4687767..4689677 - 1911 WP_009486549.1 BglG family transcription antiterminator -
HRS02_RS22790 4689700..4690854 - 1155 WP_002886900.1 lactonase family protein -
HRS02_RS22795 4690921..4691661 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T37633 WP_009486548.1 NZ_AP023337:c4687457-4687173 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T37633 NZ_AP023337:c4687457-4687173 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT37633 WP_002886901.1 NZ_AP023337:c4687689-4687447 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT37633 NZ_AP023337:c4687689-4687447 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References