Detailed information of TA system TA037615

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 200429..200928
• Replicon: plasmid pTY66_01
• Accession: NZ_AP023334
• Organism: Mycolicibacterium sp. TY66

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1S1LJN6
• Locus tag: MTY66_RS30580
• Protein ID: WP_070947462.1
• Coordinates: 200674..200928 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MTY66_RS30575
• Protein ID: WP_212815057.1
• Coordinates: 200429..200677 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTY66_RS30550 (MTY66_62660)	195990..197174	+	1185	WP_212815052.1	hypothetical protein	-
MTY66_RS30555	197208..197495	+	288	WP_212815053.1	hypothetical protein	-
MTY66_RS30560 (MTY66_62670)	197492..199108	+	1617	WP_212815054.1	hypothetical protein	-
MTY66_RS30565 (MTY66_62680)	199157..199312	+	156	WP_212815055.1	hypothetical protein	-
MTY66_RS30570 (MTY66_62700)	199949..200338	-	390	WP_212815056.1	hypothetical protein	-
MTY66_RS30575 (MTY66_62710)	200429..200677	+	249	WP_212815057.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MTY66_RS30580 (MTY66_62720)	200674..200928	+	255	WP_070947462.1	Txe/YoeB family addiction module toxin	Toxin
MTY66_RS30585 (MTY66_62730)	201011..201481	-	471	WP_070947461.1	hypothetical protein	-
MTY66_RS30590 (MTY66_62740)	201484..201762	-	279	WP_070947460.1	hypothetical protein	-
MTY66_RS30595 (MTY66_62750)	201759..202634	-	876	WP_070947459.1	ParA family protein	-
MTY66_RS30600 (MTY66_62760)	202778..204433	-	1656	WP_244873003.1	chromosome partitioning protein ParB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..266554	266554

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-71)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9561.92 Da
• Isoelectric Point: 8.9186

>T37615 WP_070947462.1 NZ_AP023334:200674-200928 [Mycolicibacterium sp. TY66]
MNIVFSPQAWEDYQYWRSAQAPLLGRINRLIVDACRSPGDGIGRPEPLKYGIAGAWSRRITAEHRLVYRVVGDDLQLVAI
GHHY

Nucleotide

• Length: 255 bp

>T37615 NZ_AP023334:200674-200928 [Mycolicibacterium sp. TY66]
ATGAACATCGTCTTTTCGCCCCAAGCGTGGGAGGACTACCAGTACTGGCGCTCCGCCCAGGCGCCTCTGCTGGGCCGGAT
CAATCGGCTCATTGTCGACGCGTGCCGGTCCCCCGGCGACGGGATCGGGAGGCCAGAGCCGCTCAAGTACGGCATCGCTG
GGGCGTGGTCGCGGCGGATAACTGCCGAGCACCGCTTGGTGTACCGAGTGGTGGGCGATGACCTTCAACTCGTTGCGATC
GGGCATCACTACTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8903.08 Da
• Isoelectric Point: 4.5203

>AT37615 WP_212815057.1 NZ_AP023334:200429-200677 [Mycolicibacterium sp. TY66]
MAITASEARKRLFPLIEQVNNDRMPVEITSKGGDAVLMAADEWAAWQETAYLFQSPENARRLLDAAAALDRGLGVRGGLS
EA

Nucleotide

• Length: 249 bp

>AT37615 NZ_AP023334:200429-200677 [Mycolicibacterium sp. TY66]
ATGGCCATTACGGCGAGCGAAGCGCGCAAGCGCCTGTTCCCGCTCATCGAGCAAGTCAACAACGATCGCATGCCCGTAGA
AATCACTTCCAAAGGTGGCGACGCGGTGCTGATGGCGGCCGACGAGTGGGCGGCGTGGCAGGAGACGGCGTACCTGTTTC
AGTCACCGGAGAACGCTCGGCGGCTCCTCGACGCGGCCGCTGCTCTTGATCGCGGTTTGGGCGTGCGGGGCGGACTTTCC
GAGGCATGA

Structures

Toxin

• AlphaFold DB: A0A1S1LJN6