Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 5769119..5769771 Replicon chromosome
Accession NZ_AP023333
Organism Mycolicibacterium sp. TY66

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag MTY66_RS27445 Protein ID WP_212813148.1
Coordinates 5769119..5769556 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag MTY66_RS27450 Protein ID WP_212813150.1
Coordinates 5769559..5769771 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTY66_RS27415 (MTY66_56450) 5764642..5765232 - 591 WP_212813122.1 GNAT family protein -
MTY66_RS27420 (MTY66_56460) 5765229..5765639 - 411 WP_212813124.1 hypothetical protein -
MTY66_RS27425 (MTY66_56470) 5765702..5766142 + 441 WP_212813126.1 cupin domain-containing protein -
MTY66_RS27430 (MTY66_56480) 5766148..5767827 + 1680 WP_212813136.1 NAD-binding protein -
MTY66_RS27435 (MTY66_56490) 5767835..5768095 - 261 WP_212813138.1 hypothetical protein -
MTY66_RS27440 (MTY66_56500) 5768203..5768973 - 771 WP_212813140.1 VOC family protein -
MTY66_RS27445 (MTY66_56510) 5769119..5769556 - 438 WP_212813148.1 SRPBCC family protein Toxin
MTY66_RS27450 (MTY66_56520) 5769559..5769771 - 213 WP_212813150.1 antitoxin Antitoxin
MTY66_RS27455 (MTY66_56530) 5769821..5772229 - 2409 WP_212813152.1 HAD-IC family P-type ATPase -
MTY66_RS27460 (MTY66_56540) 5772303..5773418 - 1116 WP_212813154.1 MBL fold metallo-hydrolase -
MTY66_RS27465 (MTY66_56550) 5773418..5774152 - 735 WP_020098935.1 enoyl-CoA hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15550.03 Da        Isoelectric Point: 9.5944

>T37614 WP_212813148.1 NZ_AP023333:c5769556-5769119 [Mycolicibacterium sp. TY66]
MAKLASSIEVPLSPEKAWEAASDLSRYDDWLSIHRMWRSPLPETLGKGTQISSVVEVKGMLNRVDWTIVHYNPPGSLTLN
GVGKGGVRVKLMAKITPAGDGSNVAFDIHLGGPALFGPIGMVVAAALRSDIHQSLEKFKALFASV

Download         Length: 438 bp

>T37614 NZ_AP023333:c5769556-5769119 [Mycolicibacterium sp. TY66]
ATGGCAAAACTCGCAAGTTCCATCGAAGTACCGCTGTCGCCCGAAAAGGCCTGGGAGGCAGCGTCGGACCTCTCCCGGTA
TGACGACTGGCTGTCCATCCACCGGATGTGGCGCAGCCCGTTGCCCGAGACCCTGGGGAAGGGCACGCAGATCTCGTCCG
TCGTCGAGGTCAAGGGCATGCTGAACCGGGTCGACTGGACCATCGTGCATTACAACCCGCCGGGATCGTTGACCCTCAAC
GGCGTCGGCAAGGGTGGGGTCCGGGTCAAGTTGATGGCCAAGATCACGCCGGCCGGCGACGGTTCGAACGTGGCGTTCGA
CATCCACCTCGGTGGCCCGGCCCTGTTCGGACCCATCGGTATGGTGGTGGCAGCTGCGCTGCGGTCCGACATCCACCAGT
CACTGGAGAAGTTCAAGGCGCTGTTCGCGTCGGTGTAG

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7258.01 Da        Isoelectric Point: 4.2092

>AT37614 WP_212813150.1 NZ_AP023333:c5769771-5769559 [Mycolicibacterium sp. TY66]
MGFLDKVKDLAAQNADKVEAAIEKVGDIVDEKTEGKFKGAVDSAQEAAKKAVAGDQPAAEAPAEGTQEQQ

Download         Length: 213 bp

>AT37614 NZ_AP023333:c5769771-5769559 [Mycolicibacterium sp. TY66]
ATGGGATTTCTGGACAAGGTGAAGGACCTGGCGGCGCAGAACGCCGACAAGGTCGAGGCCGCTATCGAGAAGGTCGGCGA
CATCGTCGACGAGAAGACCGAAGGCAAGTTCAAGGGCGCTGTCGACAGCGCCCAGGAAGCGGCGAAGAAGGCCGTCGCAG
GAGACCAGCCTGCTGCTGAGGCTCCTGCCGAGGGGACGCAAGAACAGCAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References