Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 4057645..4058306 Replicon chromosome
Accession NZ_AP023333
Organism Mycolicibacterium sp. TY66

Toxin (Protein)


Gene name vapC Uniprot ID A0A4R5W8S0
Locus tag MTY66_RS19195 Protein ID WP_061001017.1
Coordinates 4057881..4058306 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A4R5W7M0
Locus tag MTY66_RS19190 Protein ID WP_061001016.1
Coordinates 4057645..4057884 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTY66_RS19180 (MTY66_39180) 4055481..4056092 - 612 WP_234785328.1 DUF4194 domain-containing protein -
MTY66_RS19185 (MTY66_39190) 4056089..4057543 - 1455 WP_061001015.1 DUF3375 domain-containing protein -
MTY66_RS19190 (MTY66_39200) 4057645..4057884 + 240 WP_061001016.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MTY66_RS19195 (MTY66_39210) 4057881..4058306 + 426 WP_061001017.1 type II toxin-antitoxin system VapC family toxin Toxin
MTY66_RS19200 (MTY66_39220) 4058568..4059044 - 477 WP_064860476.1 DIP1984 family protein -
MTY66_RS19205 (MTY66_39230) 4059163..4059447 - 285 WP_061001018.1 hypothetical protein -
MTY66_RS19210 (MTY66_39250) 4059765..4060391 - 627 WP_212811945.1 dihydrofolate reductase family protein -
MTY66_RS19215 (MTY66_39260) 4060470..4061744 - 1275 WP_133428395.1 hypothetical protein -
MTY66_RS19220 (MTY66_39270) 4061754..4062647 - 894 WP_234790304.1 class A beta-lactamase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-126)

Antitoxin

SpoVT-AbrB domain

(4-40)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 14535.33 Da        Isoelectric Point: 5.8813

>T37613 WP_061001017.1 NZ_AP023333:4057881-4058306 [Mycolicibacterium sp. TY66]
MTSQQVTAIDTSVAVPLLVSSHPQHVAVSQWAMGRRLGLSGHALAETYSVLTRLPGDARVDPADAVALIDDNFPEPLQLG
ADTGRGAHHEFARCGVAGGATYDGLVALAAREHGAVLVTRDARAKATYDALGVNAEVLAGA

Download         Length: 426 bp

>T37613 NZ_AP023333:4057881-4058306 [Mycolicibacterium sp. TY66]
CTGACGTCGCAGCAGGTCACGGCAATCGATACCAGCGTCGCGGTGCCCTTGCTTGTGTCCTCGCATCCGCAGCACGTCGC
GGTCTCGCAATGGGCAATGGGCCGACGTCTTGGGCTCAGCGGGCATGCGCTGGCCGAGACATACTCGGTTCTGACGCGTC
TGCCCGGCGATGCTCGTGTCGACCCTGCCGACGCGGTGGCGTTGATCGACGACAACTTCCCGGAGCCCCTTCAACTGGGT
GCCGACACGGGACGCGGTGCCCATCACGAATTCGCCCGTTGTGGCGTCGCGGGCGGCGCCACCTATGACGGCTTGGTCGC
GTTGGCCGCTCGTGAGCACGGTGCAGTCCTGGTCACTCGCGATGCCAGAGCCAAGGCAACCTACGACGCCCTCGGGGTAA
ACGCGGAAGTGCTGGCCGGCGCCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8336.60 Da        Isoelectric Point: 8.7166

>AT37613 WP_061001016.1 NZ_AP023333:4057645-4057884 [Mycolicibacterium sp. TY66]
MEAVIDSGGRILVPKQLRDALGLTPGSTVDISAYGPGLQIVPGGRSARLVRNKDGRLVANADTVVTDEMMFALIDSGRR

Download         Length: 240 bp

>AT37613 NZ_AP023333:4057645-4057884 [Mycolicibacterium sp. TY66]
ATGGAAGCGGTAATCGACTCGGGCGGCCGCATCTTGGTGCCCAAGCAACTCCGCGACGCGTTGGGACTGACGCCCGGTTC
GACGGTCGATATTTCGGCATATGGCCCTGGACTGCAGATTGTCCCCGGCGGCCGCTCCGCGCGCCTCGTGCGAAACAAGG
ACGGACGCCTCGTCGCCAACGCAGACACAGTCGTCACCGATGAAATGATGTTCGCGCTCATCGATTCGGGGCGACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4R5W8S0

Antitoxin

Source ID Structure
AlphaFold DB A0A4R5W7M0

References