Detailed information of TA system TA037612

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 4050497..4051098
• Replicon: chromosome
• Accession: NZ_AP023333
• Organism: Mycolicibacterium sp. TY66

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MTY66_RS19165
• Protein ID: WP_212811942.1
• Coordinates: 4050697..4051098 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MTY66_RS19160
• Protein ID: WP_133425925.1
• Coordinates: 4050497..4050700 (+)
• Length: 68 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTY66_RS19155 (MTY66_39130)	4046551..4049883	+	3333	WP_205848809.1	Swt1 family HEPN domain-containing protein	-
MTY66_RS19160 (MTY66_39140)	4050497..4050700	+	204	WP_133425925.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
MTY66_RS19165 (MTY66_39150)	4050697..4051098	+	402	WP_212811942.1	PIN domain nuclease	Toxin
MTY66_RS19170 (MTY66_39160)	4051081..4052217	-	1137	WP_212811943.1	DUF3322 domain-containing protein	-
MTY66_RS19175 (MTY66_39170)	4052210..4055488	-	3279	WP_212811944.1	ATP-binding protein	-
MTY66_RS19180 (MTY66_39180)	4055481..4056092	-	612	WP_234785328.1	DUF4194 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-120)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-41)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14802.97 Da
• Isoelectric Point: 6.0803

>T37612 WP_212811942.1 NZ_AP023333:4050697-4051098 [Mycolicibacterium sp. TY66]
MILVDTSAWIEFLRNTGSGVCVRVDELLAEPIAICAPVQMEILAGARNDRHLKDLRGLLARAQTLPTSPTDYEDAATIYR
VCRRRGETVRKVIDCLIAAHAIREQIPILHSDSDFDAIARHTSLQLDTSPRPD

Nucleotide

• Length: 402 bp

>T37612 NZ_AP023333:4050697-4051098 [Mycolicibacterium sp. TY66]
ATGATCCTCGTTGACACGTCAGCCTGGATCGAGTTTCTAAGGAACACCGGGAGCGGTGTGTGCGTGCGAGTCGACGAGCT
ACTCGCCGAGCCGATCGCGATCTGCGCTCCCGTCCAGATGGAAATCCTCGCCGGGGCCCGAAACGACCGCCACCTCAAGG
ATCTTCGTGGCCTGTTGGCACGCGCACAAACTCTACCGACATCCCCCACTGACTATGAAGACGCCGCAACCATTTACCGC
GTCTGTCGGCGTCGCGGTGAAACCGTACGCAAAGTGATCGACTGCCTCATCGCCGCGCATGCCATACGCGAACAGATTCC
AATCCTGCACTCCGACAGCGACTTCGACGCGATCGCGCGGCATACATCGCTACAGCTGGATACCTCACCGCGGCCGGACT
GA

Antitoxin

Protein

• Length: 68 a.a.
• Molecular weight: 7754.72 Da
• Isoelectric Point: 6.4577

>AT37612 WP_133425925.1 NZ_AP023333:4050497-4050700 [Mycolicibacterium sp. TY66]
MTRTNIDIDDHACEVVMRRFHLTSKRDAVNFALRNLAQEALDLKAARELRGSGWDADLDELRSDRVR

Nucleotide

• Length: 204 bp

>AT37612 NZ_AP023333:4050497-4050700 [Mycolicibacterium sp. TY66]
ATGACCCGCACAAACATCGACATCGACGACCATGCGTGCGAGGTCGTCATGCGAAGGTTCCATTTGACCAGCAAGCGAGA
CGCGGTGAACTTCGCGTTGCGCAATCTCGCCCAGGAAGCATTGGACCTCAAAGCGGCCCGAGAACTCCGCGGGTCCGGAT
GGGACGCCGATCTCGATGAATTGCGCAGCGACCGCGTCCGATGA