Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 3219215..3220188 Replicon chromosome
Accession NZ_AP023333
Organism Mycolicibacterium sp. TY66

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag MTY66_RS15250 Protein ID WP_212811428.1
Coordinates 3219215..3219790 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag MTY66_RS15255 Protein ID WP_212811429.1
Coordinates 3219787..3220188 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTY66_RS15225 (MTY66_30940) 3214946..3215737 - 792 WP_061010194.1 SDR family NAD(P)-dependent oxidoreductase -
MTY66_RS15230 (MTY66_30950) 3215818..3216396 - 579 WP_212811425.1 TetR/AcrR family transcriptional regulator -
MTY66_RS15235 (MTY66_30960) 3216432..3216743 - 312 WP_212811426.1 NIPSNAP family protein -
MTY66_RS15240 (MTY66_30980) 3217487..3218038 - 552 WP_212811427.1 DapH/DapD/GlmU-related protein -
MTY66_RS15245 (MTY66_30990) 3218152..3218703 - 552 WP_135356156.1 YaeQ family protein -
MTY66_RS15250 (MTY66_31010) 3219215..3219790 - 576 WP_212811428.1 zeta toxin family protein Toxin
MTY66_RS15255 (MTY66_31020) 3219787..3220188 - 402 WP_212811429.1 hypothetical protein Antitoxin
MTY66_RS15260 3220298..3220444 + 147 WP_212811430.1 hypothetical protein -
MTY66_RS15265 (MTY66_31040) 3221299..3221940 - 642 WP_079481877.1 cadmium resistance transporter -
MTY66_RS15270 (MTY66_31050) 3222079..3222468 - 390 WP_005148625.1 heavy metal-responsive transcriptional regulator -
MTY66_RS15275 (MTY66_31060) 3222525..3223928 + 1404 WP_005148655.1 mercury(II) reductase -
MTY66_RS15280 (MTY66_31070) 3223955..3224596 + 642 WP_005148656.1 organomercurial lyase MerB -
MTY66_RS15285 (MTY66_31080) 3224629..3224919 + 291 WP_005148657.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-142)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 20950.93 Da        Isoelectric Point: 9.3920

>T37611 WP_212811428.1 NZ_AP023333:c3219790-3219215 [Mycolicibacterium sp. TY66]
VKRLDLVVGSNGAGKSTFVELTLAPLLPSSVFVNADEIAKQRWPTDALGHAYEAARIAAATREALIEQGRSFIAETVFSH
PSKLELIDAARHAGYVVVLHIVLIPENLAVHRVRYRVAAGGHDVPEEKIRERYRRLWTLVAAAIVRVDSAAVYDNSAASG
PQIVAQMSGGLSVDTPRWPSWTPEQLRSRWP

Download         Length: 576 bp

>T37611 NZ_AP023333:c3219790-3219215 [Mycolicibacterium sp. TY66]
GTGAAACGCCTGGACCTCGTCGTCGGCTCGAACGGTGCCGGAAAATCGACGTTCGTCGAACTCACGCTGGCTCCGCTGCT
ACCGAGCAGCGTGTTCGTCAACGCGGATGAGATCGCCAAACAGCGCTGGCCTACCGACGCTTTGGGCCACGCCTACGAGG
CCGCGCGGATCGCCGCGGCGACGCGGGAAGCGTTGATCGAGCAGGGGCGTTCATTCATCGCCGAGACCGTGTTCTCGCAC
CCCTCCAAGCTGGAGCTGATCGATGCGGCCCGTCATGCGGGGTACGTCGTGGTGTTGCACATTGTGCTGATCCCGGAGAA
CTTGGCCGTTCACCGCGTCCGCTACCGGGTTGCCGCCGGTGGCCACGATGTGCCCGAGGAGAAGATCCGGGAACGGTATC
GCCGGCTGTGGACATTGGTGGCTGCAGCGATCGTTCGCGTCGACAGCGCAGCGGTTTACGACAATTCCGCGGCCAGTGGA
CCGCAGATCGTGGCGCAGATGAGTGGCGGACTGAGCGTCGACACGCCCCGATGGCCGTCGTGGACTCCGGAACAGCTGCG
TAGTCGCTGGCCGTAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14192.69 Da        Isoelectric Point: 5.2297

>AT37611 WP_212811429.1 NZ_AP023333:c3220188-3219787 [Mycolicibacterium sp. TY66]
MSEVADRVTRVSADLFEAAAAEGARQSRSAKQQLDHWARVGRAVSTQHTASRRRVEAALAGQIDIAVLNTEEGVVFNAEV
SAAIEESLARTDYGAVLASRGITTVALDEDGQIVEHRPDGTESVVGAVHSLRR

Download         Length: 402 bp

>AT37611 NZ_AP023333:c3220188-3219787 [Mycolicibacterium sp. TY66]
ATGTCCGAAGTCGCCGATCGGGTCACCCGGGTGTCCGCTGACCTGTTCGAGGCCGCGGCCGCCGAGGGTGCCCGGCAGAG
TCGCTCCGCCAAGCAGCAACTCGACCATTGGGCGCGGGTGGGCCGCGCTGTATCGACCCAGCACACCGCTTCACGACGCA
GGGTGGAGGCTGCCCTCGCCGGTCAGATCGACATCGCCGTTCTCAACACCGAAGAAGGCGTGGTGTTCAATGCCGAGGTT
TCCGCGGCGATCGAGGAGAGTCTGGCCCGCACCGATTACGGTGCCGTGCTCGCCTCTCGTGGGATCACCACGGTGGCATT
GGATGAGGACGGCCAGATCGTCGAGCATCGCCCGGACGGCACCGAGTCCGTGGTTGGTGCGGTGCACTCGCTGCGTCGGT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References