Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1383566..1384110 Replicon chromosome
Accession NZ_AP023333
Organism Mycolicibacterium sp. TY66

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag MTY66_RS06330 Protein ID WP_073694732.1
Coordinates 1383814..1384110 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag MTY66_RS06325 Protein ID WP_073694733.1
Coordinates 1383566..1383817 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTY66_RS06305 (MTY66_12810) 1379452..1380966 + 1515 WP_212807108.1 zinc ribbon domain-containing protein -
MTY66_RS06310 (MTY66_12820) 1380929..1381555 - 627 WP_212807107.1 hypothetical protein -
MTY66_RS06315 (MTY66_12830) 1381552..1382826 - 1275 Protein_1262 NADH:flavin oxidoreductase/NADH oxidase family protein -
MTY66_RS06320 (MTY66_12850) 1382918..1383505 + 588 WP_073694734.1 TetR/AcrR family transcriptional regulator -
MTY66_RS06325 1383566..1383817 + 252 WP_073694733.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
MTY66_RS06330 (MTY66_12860) 1383814..1384110 + 297 WP_073694732.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MTY66_RS06335 (MTY66_12870) 1384141..1386351 - 2211 WP_212807106.1 AAA family ATPase -
MTY66_RS06340 (MTY66_12880) 1386348..1387238 - 891 WP_073694730.1 CDP-diacylglycerol--serine O-phosphatidyltransferase -
MTY66_RS06345 (MTY66_12890) 1387235..1387963 - 729 WP_073694729.1 phosphatidylserine decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(4-73)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11436.94 Da        Isoelectric Point: 6.6350

>T37610 WP_073694732.1 NZ_AP023333:1383814-1384110 [Mycolicibacterium sp. TY66]
VSRYVLSPAARADLEDVWDYTCERWNADQAQAYVREIQHAIERIAESPMIGRACDDVRPGYRKHAVGSHVLYYRLISGEI
IDVVRILHQRMDVPRHFD

Download         Length: 297 bp

>T37610 NZ_AP023333:1383814-1384110 [Mycolicibacterium sp. TY66]
GTGAGCCGTTATGTACTTTCGCCCGCGGCGCGCGCCGACTTGGAAGATGTCTGGGACTACACATGTGAGCGCTGGAACGC
TGATCAGGCGCAGGCGTACGTTCGGGAGATTCAACATGCCATCGAACGCATCGCGGAGTCGCCGATGATCGGGCGAGCGT
GCGACGACGTTCGCCCGGGTTACCGGAAACATGCGGTGGGATCGCACGTGCTGTATTACCGGCTCATCTCCGGGGAAATC
ATCGACGTCGTGCGCATCCTCCATCAGCGGATGGATGTGCCTCGGCACTTTGACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9510.36 Da        Isoelectric Point: 5.7425

>AT37610 WP_073694733.1 NZ_AP023333:1383566-1383817 [Mycolicibacterium sp. TY66]
VGRNTSFSLDEHYSAFIETEVASGRYRSASDVVRSALRLLEDRETRLRALRQALVDGERSGESTEFDFDEFVSRKRAEGS
HRQ

Download         Length: 252 bp

>AT37610 NZ_AP023333:1383566-1383817 [Mycolicibacterium sp. TY66]
GTGGGCAGGAACACCTCATTCAGTCTCGATGAGCACTACAGCGCGTTCATCGAGACTGAAGTCGCGTCCGGTCGTTATCG
ATCGGCCAGTGACGTAGTGCGATCCGCATTGCGACTGCTCGAGGATCGGGAGACTCGACTGAGGGCGTTGCGCCAGGCCC
TTGTGGATGGTGAACGTAGCGGTGAATCAACAGAATTCGACTTTGATGAGTTCGTATCGCGCAAACGGGCCGAGGGTTCC
CATCGTCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References