Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1146958..1147621 Replicon chromosome
Accession NZ_AP023333
Organism Mycolicibacterium sp. TY66

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MTY66_RS05150 Protein ID WP_212807252.1
Coordinates 1146958..1147386 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MTY66_RS05155 Protein ID WP_212814558.1
Coordinates 1147373..1147621 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTY66_RS05125 (MTY66_10390) 1142442..1143017 - 576 WP_212807256.1 hypothetical protein -
MTY66_RS05130 (MTY66_10400) 1143040..1144110 - 1071 WP_212807255.1 ferredoxin--NADP reductase -
MTY66_RS05135 (MTY66_10410) 1144266..1145456 + 1191 WP_212807254.1 flavin-dependent monooxygenase -
MTY66_RS05140 (MTY66_10420) 1145472..1146374 + 903 WP_212807253.1 VOC family protein -
MTY66_RS05145 (MTY66_10430) 1146386..1146955 + 570 WP_064859702.1 flavin reductase family protein -
MTY66_RS05150 (MTY66_10440) 1146958..1147386 - 429 WP_212807252.1 type II toxin-antitoxin system VapC family toxin Toxin
MTY66_RS05155 (MTY66_10450) 1147373..1147621 - 249 WP_212814558.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MTY66_RS05160 (MTY66_10460) 1147729..1149120 + 1392 WP_212807251.1 MFS transporter -
MTY66_RS05165 (MTY66_10470) 1149281..1150708 - 1428 WP_083612599.1 IS1182 family transposase -
MTY66_RS05170 (MTY66_10480) 1151183..1151398 + 216 WP_212807250.1 hypothetical protein -
MTY66_RS05175 (MTY66_10490) 1151460..1152266 - 807 WP_061006885.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-41)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15687.93 Da        Isoelectric Point: 7.3846

>T37609 WP_212807252.1 NZ_AP023333:c1147386-1146958 [Mycolicibacterium sp. TY66]
MLLVDVNIWVYAIRSDSAQHGTYREWVEEALTGSEPVGVSELVLSGVMRLITNHRIFSQPSSTAEALDACRAIRSAPSAI
SLRPGPRHWSIFEKLCTTVGAKANVVPDAYHAALAIEHGATWVTTDRAFARFPGLKWRLPFE

Download         Length: 429 bp

>T37609 NZ_AP023333:c1147386-1146958 [Mycolicibacterium sp. TY66]
ATGCTCCTCGTTGACGTCAACATCTGGGTCTATGCCATCCGCAGCGACAGTGCCCAGCACGGCACCTATCGAGAATGGGT
CGAAGAAGCGCTCACCGGCTCCGAACCAGTAGGCGTCAGCGAATTGGTGCTTTCCGGCGTCATGCGACTGATCACCAACC
ACCGGATTTTCTCGCAACCAAGCTCGACGGCAGAAGCTCTCGACGCATGCCGCGCGATCCGCTCAGCACCGTCGGCGATA
TCGCTACGGCCCGGACCCCGTCATTGGTCAATATTCGAAAAACTGTGCACGACCGTCGGCGCCAAGGCCAATGTCGTCCC
GGATGCCTACCACGCGGCGCTCGCGATCGAACACGGCGCCACATGGGTCACCACGGACCGGGCCTTCGCCCGCTTTCCAG
GTCTGAAGTGGCGCCTACCTTTTGAGTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8613.67 Da        Isoelectric Point: 5.0069

>AT37609 WP_212814558.1 NZ_AP023333:c1147621-1147373 [Mycolicibacterium sp. TY66]
MRTTVNIDDHLLEEAKVLAARTSRSLGSVVEDGLRALLHRNNPGTSVGTFVLPTHGIGGLAPGVDLEDKDALAELTGDNA
PR

Download         Length: 249 bp

>AT37609 NZ_AP023333:c1147621-1147373 [Mycolicibacterium sp. TY66]
ATGCGCACCACCGTCAACATCGACGATCACCTACTGGAAGAGGCCAAGGTGCTCGCGGCCAGGACATCCCGAAGCCTGGG
CTCGGTGGTCGAGGACGGACTTCGGGCATTGCTGCACCGAAACAACCCCGGCACGAGCGTCGGCACATTCGTGCTTCCAA
CCCATGGGATCGGCGGCCTTGCCCCCGGGGTCGATCTGGAAGACAAAGACGCCCTCGCCGAACTGACCGGCGACAATGCT
CCTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References