Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3075227..3075810 Replicon chromosome
Accession NZ_AP023326
Organism Acetobacter aceti strain JCM20276

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag AAJCM20276_RS14210 Protein ID WP_099349103.1
Coordinates 3075556..3075810 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag AAJCM20276_RS14205 Protein ID WP_099349102.1
Coordinates 3075227..3075559 (-) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AAJCM20276_RS14190 3070369..3072087 + 1719 WP_145995962.1 hypothetical protein -
AAJCM20276_RS14195 3072228..3073685 - 1458 WP_099349100.1 hypothetical protein -
AAJCM20276_RS14200 3073834..3075006 - 1173 WP_180952885.1 site-specific integrase -
AAJCM20276_RS14205 3075227..3075559 - 333 WP_099349102.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
AAJCM20276_RS14210 3075556..3075810 - 255 WP_099349103.1 type II toxin-antitoxin system HicA family toxin Toxin
AAJCM20276_RS14215 3075977..3076167 - 191 Protein_2793 transposase -
AAJCM20276_RS14220 3076598..3078031 + 1434 WP_099349104.1 DNA photolyase family protein -
AAJCM20276_RS14225 3078170..3078871 + 702 WP_099349105.1 pirin family protein -
AAJCM20276_RS14230 3079159..3079779 + 621 WP_099349106.1 hypothetical protein -
AAJCM20276_RS14235 3079926..3080357 + 432 WP_145995964.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3064077..3080357 16280


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-77)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9520.05 Da        Isoelectric Point: 10.0990

>T37607 WP_099349103.1 NZ_AP023326:c3075810-3075556 [Acetobacter aceti]
MKAKHRRTLELIFKRPVCGNVPWADIEALFIALGGEVSEREGSRIGVFLFGEIRVFHRPHPKPDTDKGAVAAVRKWLEQN
EVTP

Download         Length: 255 bp

>T37607 NZ_AP023326:c3075810-3075556 [Acetobacter aceti]
ATGAAAGCCAAACATCGCCGCACGCTGGAGCTGATCTTCAAGCGCCCCGTTTGCGGCAATGTGCCATGGGCCGACATCGA
AGCCCTGTTCATCGCTCTGGGTGGTGAGGTGTCGGAACGGGAAGGCTCCCGCATTGGCGTGTTCCTGTTTGGAGAAATCC
GGGTCTTCCATCGCCCGCACCCCAAACCGGACACCGATAAGGGCGCTGTCGCAGCGGTGCGAAAATGGCTTGAGCAGAAT
GAGGTGACACCATGA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12021.63 Da        Isoelectric Point: 4.6967

>AT37607 WP_099349102.1 NZ_AP023326:c3075559-3075227 [Acetobacter aceti]
MNNMMEISGHRAVIQFDPEIGLFRGEFVGLNGGADFYADSVEGLQQEGETSLRVFLEMCAEKGVEPVKHYSGKFQVRLPP
EAHARAVEMAAARGVSLNRLVQDVLEQAAG

Download         Length: 333 bp

>AT37607 NZ_AP023326:c3075559-3075227 [Acetobacter aceti]
ATGAACAACATGATGGAGATCAGCGGCCATCGGGCCGTCATTCAGTTTGATCCTGAGATTGGCCTGTTCCGGGGCGAGTT
CGTCGGCCTCAATGGCGGGGCCGACTTTTACGCCGACAGCGTGGAAGGTCTTCAGCAGGAAGGGGAAACATCCCTGCGTG
TTTTTCTGGAGATGTGCGCCGAGAAAGGTGTCGAGCCTGTGAAGCACTATTCCGGCAAATTCCAGGTGCGTCTGCCACCT
GAAGCGCACGCCCGGGCCGTCGAGATGGCAGCGGCGCGCGGCGTCAGTCTGAACCGTCTGGTTCAGGATGTTCTGGAGCA
GGCTGCGGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References