Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 655622..656201 Replicon chromosome
Accession NZ_AP023326
Organism Acetobacter aceti strain JCM20276

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AAJCM20276_RS03145 Protein ID WP_185230000.1
Coordinates 655622..656008 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag AAJCM20276_RS03150 Protein ID WP_099349564.1
Coordinates 655998..656201 (-) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AAJCM20276_RS03115 651238..651834 - 597 WP_185229999.1 recombinase family protein -
AAJCM20276_RS03120 652028..652705 + 678 WP_099349521.1 hypothetical protein -
AAJCM20276_RS03125 652734..653087 + 354 WP_145995996.1 hypothetical protein -
AAJCM20276_RS03130 653063..653413 - 351 WP_099349523.1 hypothetical protein -
AAJCM20276_RS03135 653779..654042 - 264 WP_099349524.1 hypothetical protein -
AAJCM20276_RS03140 654695..655363 - 669 WP_099349560.1 recombinase family protein -
AAJCM20276_RS03145 655622..656008 - 387 WP_185230000.1 PIN domain-containing protein Toxin
AAJCM20276_RS03150 655998..656201 - 204 WP_099349564.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
AAJCM20276_RS03155 656313..656825 - 513 WP_185230001.1 type II secretion system protein -
AAJCM20276_RS03160 657119..657442 + 324 WP_180952916.1 MobC family plasmid mobilization relaxosome protein -
AAJCM20276_RS03165 657439..658173 + 735 WP_185230002.1 hypothetical protein -
AAJCM20276_RS03170 658218..659153 + 936 WP_185230003.1 hypothetical protein -
AAJCM20276_RS03175 659486..659947 + 462 WP_185230004.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 641153..664939 23786


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-110)

Antitoxin

SpoVT-AbrB domain

(5-34)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14430.74 Da        Isoelectric Point: 4.8484

>T37606 WP_185230000.1 NZ_AP023326:c656008-655622 [Acetobacter aceti]
MLLDSNVILYGIIQDDRKTPIAARLMEQGGFLSVQTLNEVTNVLRKKKKDWEFINRLLEDLYISFSVLPMDIEVHKAGVK
IAGRYGLSTYDSMIVACAYVNGIETVLSEDMQNGQVIFDTVRIVNPFG

Download         Length: 387 bp

>T37606 NZ_AP023326:c656008-655622 [Acetobacter aceti]
ATGCTTCTTGATTCCAATGTCATTCTGTATGGCATCATTCAGGATGACAGAAAGACGCCAATCGCTGCCAGACTGATGGA
ACAGGGTGGCTTCCTCAGTGTCCAGACACTGAATGAAGTGACCAATGTCCTGCGGAAGAAAAAGAAGGACTGGGAGTTCA
TCAACAGACTTCTGGAAGACCTGTATATCTCCTTTTCCGTTCTACCTATGGATATCGAAGTTCATAAGGCAGGCGTGAAG
ATAGCTGGACGTTATGGTCTGTCTACATATGATTCCATGATTGTGGCCTGTGCTTACGTGAATGGGATTGAGACCGTGCT
GTCCGAGGATATGCAGAATGGACAGGTCATCTTCGATACTGTCAGGATCGTCAATCCATTTGGGTAG

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7684.82 Da        Isoelectric Point: 10.4777

>AT37606 WP_099349564.1 NZ_AP023326:c656201-655998 [Acetobacter aceti]
MQVSKWGNSLAVRIPRHMLKEHGIQEGDNVEITIRRVKSRKEALTDLKELGKQLPADFRIERTSDAS

Download         Length: 204 bp

>AT37606 NZ_AP023326:c656201-655998 [Acetobacter aceti]
ATGCAGGTCTCGAAATGGGGGAACAGTCTGGCCGTTCGTATCCCCCGTCACATGCTGAAGGAGCACGGGATTCAGGAAGG
TGATAACGTGGAGATCACCATCAGACGGGTGAAATCCCGCAAGGAAGCCCTGACTGACCTGAAAGAACTTGGAAAGCAGT
TGCCTGCTGACTTCCGTATCGAACGGACTTCTGATGCTTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References