Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 516013..516592 Replicon chromosome
Accession NZ_AP023326
Organism Acetobacter aceti strain JCM20276

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AAJCM20276_RS02450 Protein ID WP_185229983.1
Coordinates 516013..516399 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag AAJCM20276_RS02455 Protein ID WP_099349548.1
Coordinates 516389..516592 (-) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AAJCM20276_RS02410 511532..511912 + 381 WP_185229981.1 hypothetical protein -
AAJCM20276_RS02415 511922..512326 + 405 WP_145995934.1 hypothetical protein -
AAJCM20276_RS02420 512403..512636 - 234 WP_145995935.1 hypothetical protein -
AAJCM20276_RS02425 512913..513467 + 555 WP_099348480.1 site-specific DNA-methyltransferase -
AAJCM20276_RS02430 513535..514023 + 489 WP_145995936.1 hypothetical protein -
AAJCM20276_RS02435 514025..514369 - 345 WP_099348482.1 hypothetical protein -
AAJCM20276_RS02440 514467..514760 - 294 WP_180952837.1 hypothetical protein -
AAJCM20276_RS02445 515343..515903 - 561 WP_185229982.1 recombinase family protein -
AAJCM20276_RS02450 516013..516399 - 387 WP_185229983.1 PIN domain-containing protein Toxin
AAJCM20276_RS02455 516389..516592 - 204 WP_099349548.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
AAJCM20276_RS02460 516722..516805 - 84 Protein_478 IS5/IS1182 family transposase -
AAJCM20276_RS02465 516792..516932 - 141 WP_180952929.1 hypothetical protein -
AAJCM20276_RS02470 516997..517509 - 513 WP_185229984.1 type II secretion system protein -
AAJCM20276_RS02475 517803..518126 + 324 WP_180952916.1 MobC family plasmid mobilization relaxosome protein -
AAJCM20276_RS02480 518123..519838 + 1716 WP_185229985.1 hypothetical protein -
AAJCM20276_RS02485 519938..520471 + 534 WP_185229986.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-110)

Antitoxin

SpoVT-AbrB domain

(5-34)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14462.69 Da        Isoelectric Point: 4.4128

>T37605 WP_185229983.1 NZ_AP023326:c516399-516013 [Acetobacter aceti]
MLLDSNIILYGIIQDDRKTPIADRLMEQGGFLSVQTLNEVTNVLRKKKKDWEFINRLLEDLYISFSVLPMDIEVHKAGVT
IAGRYGLSTYDSMIIGCAYVNGIETVLSEDMQDGQVIFDTVRIVNPFG

Download         Length: 387 bp

>T37605 NZ_AP023326:c516399-516013 [Acetobacter aceti]
ATGCTTCTTGATTCCAATATCATTCTGTATGGCATCATTCAGGATGACAGAAAGACGCCAATTGCCGACAGGCTGATGGA
GCAAGGGGGTTTCCTCAGTGTCCAGACACTGAATGAAGTGACCAATGTCCTGCGGAAGAAAAAGAAGGACTGGGAGTTCA
TCAACAGGCTACTGGAAGACCTGTATATCTCCTTCTCTGTCCTGCCTATGGATATCGAAGTCCATAAGGCGGGAGTGACG
ATAGCCGGACGTTATGGTCTGTCGACATATGATTCCATGATTATTGGATGTGCTTACGTGAATGGGATTGAGACCGTGCT
GTCCGAGGATATGCAGGATGGACAGGTCATCTTCGATACTGTCAGGATCGTCAATCCATTTGGGTAG

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7613.70 Da        Isoelectric Point: 10.1809

>AT37605 WP_099349548.1 NZ_AP023326:c516592-516389 [Acetobacter aceti]
MQVSKWGNSLAVRIPSHMLKEHGIQEGDNVEITIRRVKSRKEALADLKELGRQLPADFRIERTSDAS

Download         Length: 204 bp

>AT37605 NZ_AP023326:c516592-516389 [Acetobacter aceti]
ATGCAGGTCTCGAAATGGGGAAACAGTCTGGCCGTTCGCATCCCCAGTCACATGCTGAAGGAGCACGGGATTCAGGAAGG
TGATAACGTGGAGATCACTATCAGACGGGTGAAATCCCGCAAGGAAGCCTTGGCTGATCTGAAAGAACTGGGGAGACAGT
TGCCTGCCGACTTCCGTATCGAACGGACTTCTGATGCTTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References