Detailed information of TA system TA037603

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ParST/RES-Xre
• Location: 3566002..3566996
• Replicon: chromosome
• Accession: NZ_AP023323
• Organism: Sphingomonas paucimobilis strain Kira

Toxin (Protein)

• Gene name: ParT
• Uniprot ID: -
• Locus tag: SPKIRA_RS16540
• Protein ID: WP_182926589.1
• Coordinates: 3566002..3566487 (-)
• Length: 162 a.a.

Antitoxin (Protein)

• Gene name: ParS
• Uniprot ID: -
• Locus tag: SPKIRA_RS16545
• Protein ID: WP_182926590.1
• Coordinates: 3566484..3566996 (-)
• Length: 171 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SPKIRA_RS16520	3561349..3561656	-	308	Protein_3246	helix-turn-helix transcriptional regulator	-
SPKIRA_RS16525	3561859..3562405	+	547	Protein_3247	hypothetical protein	-
SPKIRA_RS16530	3562640..3564514	+	1875	WP_182926584.1	molecular chaperone DnaK	-
SPKIRA_RS16535	3564589..3565128	+	540	WP_182926587.1	nucleotide exchange factor GrpE	-
SPKIRA_RS16540	3566002..3566487	-	486	WP_182926589.1	RES family NAD+ phosphorylase	Toxin
SPKIRA_RS16545	3566484..3566996	-	513	WP_182926590.1	MbcA/ParS/Xre antitoxin family protein	Antitoxin
SPKIRA_RS16550	3567110..3568087	-	978	WP_182926592.1	hypothetical protein	-
SPKIRA_RS16555	3568084..3568905	-	822	WP_182926594.1	hypothetical protein	-
SPKIRA_RS16560	3569292..3570488	-	1197	Protein_3254	IS256 family transposase	-
SPKIRA_RS16565	3570542..3571483	+	942	WP_182926596.1	IS5 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (5-153)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (43-103)

Sequences

Toxin

Protein

• Length: 162 a.a.
• Molecular weight: 17446.84 Da
• Isoelectric Point: 7.1664

>T37603 WP_182926589.1 NZ_AP023323:c3566487-3566002 [Sphingomonas paucimobilis]
VSQRLFRIATDTKTYTADDMRGTGAKLTGGRWNDVGVAVVYSSPTRALACLETLVHLNAGGLPLNRYLVEIEVPDDLWAA
AESTAASSLPVGWDAEPAGLVSTTFGTDWANSGRSALLMVPSVVIPEELNVLINPGHRDAGRIAARKVRKWIYDPRMDRR
A

Nucleotide

• Length: 486 bp

>T37603 NZ_AP023323:c3566487-3566002 [Sphingomonas paucimobilis]
GTGAGCCAGCGGCTGTTTCGGATTGCCACGGATACCAAGACCTACACGGCCGACGACATGAGGGGCACGGGCGCCAAGCT
TACCGGCGGCCGCTGGAATGATGTGGGGGTCGCTGTCGTCTATTCCTCCCCCACCCGTGCCCTCGCCTGCCTCGAAACTC
TCGTCCATCTGAATGCTGGCGGTTTGCCGCTCAATCGGTATCTTGTCGAAATCGAGGTTCCGGACGATCTATGGGCGGCC
GCAGAGAGCACGGCGGCTTCGTCGCTGCCTGTAGGCTGGGATGCGGAGCCGGCGGGCCTGGTGAGCACGACCTTCGGGAC
CGACTGGGCCAATAGTGGCCGATCTGCGCTTCTGATGGTCCCTTCGGTGGTCATCCCGGAAGAGCTGAACGTCCTGATCA
ATCCGGGGCATCGCGATGCCGGAAGGATTGCGGCCCGAAAGGTGCGCAAATGGATTTACGATCCGAGGATGGACAGAAGA
GCTTGA

Antitoxin

Protein

• Length: 171 a.a.
• Molecular weight: 18528.28 Da
• Isoelectric Point: 6.2500

>AT37603 WP_182926590.1 NZ_AP023323:c3566996-3566484 [Sphingomonas paucimobilis]
MIHITAQRSSSVAHASAAQRKADPAFPPSFPYVDLFRAAPVERIEFIKAGVSARKVKILITELHLDQNVMFDALSLKTAT
VNRKAARDEVLSVEESERVVGLAKLVGQLEAMVEESGAGEDFDAPTWLSRWLREPLPALKGAKPIDFLDTMEGQALVSRA
LAQIQSGAYA

Nucleotide

• Length: 513 bp

>AT37603 NZ_AP023323:c3566996-3566484 [Sphingomonas paucimobilis]
ATGATCCATATAACTGCTCAAAGGAGCAGTTCCGTGGCCCACGCATCCGCCGCTCAGAGGAAAGCCGACCCGGCGTTCCC
GCCCTCATTTCCCTATGTCGACCTGTTTCGGGCCGCACCCGTGGAGCGCATCGAGTTCATCAAGGCCGGCGTTTCTGCGC
GCAAGGTCAAGATTCTCATCACCGAGCTCCACCTGGACCAGAACGTCATGTTCGATGCGCTCAGCCTCAAGACCGCAACC
GTCAACCGAAAGGCCGCTCGAGACGAGGTTCTGTCCGTCGAGGAGAGCGAGCGCGTCGTGGGTCTCGCGAAGCTCGTCGG
CCAGCTGGAAGCAATGGTCGAAGAGTCCGGAGCGGGTGAGGATTTCGATGCGCCCACCTGGCTATCCCGCTGGCTGCGCG
AACCGCTGCCCGCGCTCAAAGGCGCCAAGCCGATCGATTTTCTGGACACGATGGAGGGCCAAGCTCTCGTGTCGCGTGCG
CTCGCTCAGATCCAGAGCGGAGCCTATGCGTGA