Detailed information of TA system TA037602

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 3505746..3506419
• Replicon: chromosome
• Accession: NZ_AP023323
• Organism: Sphingomonas paucimobilis strain Kira

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: SPKIRA_RS16240
• Protein ID: WP_160987300.1
• Coordinates: 3505746..3506168 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A0G3XGK1
• Locus tag: SPKIRA_RS16245
• Protein ID: WP_012110103.1
• Coordinates: 3506165..3506419 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SPKIRA_RS16205	3501582..3501863	-	282	WP_012110094.1	helix-turn-helix domain-containing protein	-
SPKIRA_RS16210	3502000..3502629	-	630	WP_197972023.1	DUF2285 domain-containing protein	-
SPKIRA_RS16215	3502892..3503194	-	303	WP_182926511.1	DUF2285 domain-containing protein	-
SPKIRA_RS16220	3503249..3503515	-	267	WP_045811379.1	helix-turn-helix transcriptional regulator	-
SPKIRA_RS16225	3503822..3504148	-	327	WP_041535876.1	DUF736 domain-containing protein	-
SPKIRA_RS16230	3504722..3505162	-	441	WP_182926513.1	hypothetical protein	-
SPKIRA_RS16235	3505300..3505464	-	165	WP_182926515.1	hypothetical protein	-
SPKIRA_RS16240	3505746..3506168	-	423	WP_160987300.1	type II toxin-antitoxin system VapC family toxin	Toxin
SPKIRA_RS16245	3506165..3506419	-	255	WP_012110103.1	plasmid stabilization protein	Antitoxin
SPKIRA_RS16250	3506505..3507431	-	927	WP_047820987.1	DUF2493 domain-containing protein	-
SPKIRA_RS16255	3507781..3508815	-	1035	WP_182926517.1	toprim domain-containing protein	-
SPKIRA_RS16260	3508815..3510659	-	1845	WP_182926519.1	strawberry notch C-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	3486269..3521707	35438

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 14884.08 Da
• Isoelectric Point: 4.6109

>T37602 WP_160987300.1 NZ_AP023323:c3506168-3505746 [Sphingomonas paucimobilis]
MILLDTNVVSEAMKPAPDEAVRAWLDEQAAETLFLSSVTIAELMFGIGALPAGKRKERLTEALDGVMELFADRVLPFDVD
AARRYADLAVKARAAGKGFPTPDGYIAAIAAAKGFAVATRDSSAFEAANVTVIDPWKAGR

Nucleotide

• Length: 423 bp

>T37602 NZ_AP023323:c3506168-3505746 [Sphingomonas paucimobilis]
ATGATCCTCCTCGACACCAATGTCGTATCGGAGGCGATGAAGCCCGCTCCCGACGAGGCCGTGCGCGCATGGCTCGACGA
GCAGGCGGCGGAAACACTCTTTCTCTCCAGCGTCACCATCGCCGAACTGATGTTCGGCATCGGCGCGCTCCCCGCCGGCA
AGCGCAAGGAGCGTCTCACCGAAGCCCTGGATGGGGTGATGGAACTGTTCGCAGACCGCGTCCTCCCGTTCGATGTCGAT
GCTGCGCGCCGCTATGCGGATCTCGCCGTCAAAGCCCGAGCGGCCGGGAAAGGCTTCCCTACTCCCGACGGCTACATCGC
GGCGATCGCAGCCGCCAAGGGGTTTGCCGTCGCCACGCGCGACAGCAGCGCATTCGAGGCCGCGAATGTCACGGTGATCG
ATCCCTGGAAGGCCGGGCGCTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9351.67 Da
• Isoelectric Point: 10.4317

>AT37602 WP_012110103.1 NZ_AP023323:c3506419-3506165 [Sphingomonas paucimobilis]
MPAVTIRNLSDATHRALKVRAAQHGRSAEAEMRDILEMAVRPDTRLRLGTALAERSRRLGLTNEDVEALDQARDKAPAKP
MSFE

Nucleotide

• Length: 255 bp

>AT37602 NZ_AP023323:c3506419-3506165 [Sphingomonas paucimobilis]
ATGCCCGCAGTTACGATCAGGAATCTGTCCGACGCGACGCATCGCGCCCTCAAGGTGCGGGCGGCGCAGCACGGCCGCAG
CGCCGAAGCGGAAATGCGCGACATTCTCGAAATGGCTGTCCGCCCCGATACGCGCCTCCGGCTCGGCACGGCGCTCGCGG
AACGCAGCCGCCGCCTCGGCTTGACCAATGAGGATGTCGAGGCCCTCGACCAGGCTCGTGACAAGGCGCCCGCCAAGCCG
ATGAGCTTCGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0G3XGK1