Detailed information of TA system TA037601

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RHH
• Location: 3212046..3212470
• Replicon: chromosome
• Accession: NZ_AP023323
• Organism: Sphingomonas paucimobilis strain Kira

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0C9M624
• Locus tag: SPKIRA_RS14885
• Protein ID: WP_007406919.1
• Coordinates: 3212046..3212321 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: SPKIRA_RS14890
• Protein ID: WP_197913076.1
• Coordinates: 3212309..3212470 (-)
• Length: 54 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SPKIRA_RS14865	3207619..3208071	+	453	WP_007406920.1	large conductance mechanosensitive channel protein MscL	-
SPKIRA_RS14870	3208226..3208657	-	432	WP_007406932.1	Rrf2 family transcriptional regulator	-
SPKIRA_RS14880	3209448..3212018	-	2571	WP_007406927.1	DNA mismatch repair protein MutS	-
SPKIRA_RS14885	3212046..3212321	-	276	WP_007406919.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SPKIRA_RS14890	3212309..3212470	-	162	WP_197913076.1	antitoxin	Antitoxin
SPKIRA_RS14895	3212621..3214879	+	2259	WP_007406925.1	NADP-dependent malic enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-87)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10372.73 Da
• Isoelectric Point: 5.5940

>T37601 WP_007406919.1 NZ_AP023323:c3212321-3212046 [Sphingomonas paucimobilis]
MAQISWSVQASLQLAAIVDYIEQFDPDAARRLGDRLIDVAESLRQFPDRGRPISHGRREMVTVRPYVLRYEHDGETVLIL
GIRHAAQLSDD

Nucleotide

• Length: 276 bp

>T37601 NZ_AP023323:c3212321-3212046 [Sphingomonas paucimobilis]
ATGGCTCAAATAAGCTGGTCGGTTCAGGCCTCGCTCCAACTCGCCGCGATCGTCGATTATATAGAGCAGTTCGATCCCGA
CGCCGCCCGGCGCTTGGGTGACAGGCTGATCGACGTCGCCGAATCCTTGCGGCAATTCCCGGATCGCGGCAGGCCCATTT
CCCATGGCCGCCGCGAGATGGTGACGGTTCGCCCCTATGTCCTGCGCTATGAGCATGACGGCGAGACCGTCCTGATCCTC
GGCATTCGCCACGCCGCCCAACTTTCCGACGATTGA

Antitoxin

Protein

• Length: 54 a.a.
• Molecular weight: 6226.04 Da
• Isoelectric Point: 5.8087

>AT37601 WP_197913076.1 NZ_AP023323:c3212470-3212309 [Sphingomonas paucimobilis]
IFEQRDEAAELAADERARADFKAGRFVSHEKMAEWLKTWGTPDRKPLPPEWLK

Nucleotide

• Length: 162 bp

>AT37601 NZ_AP023323:c3212470-3212309 [Sphingomonas paucimobilis]
ATTTTCGAGCAGCGTGACGAGGCGGCGGAACTGGCCGCCGACGAACGCGCACGGGCCGATTTCAAGGCGGGCCGTTTCGT
AAGCCATGAGAAGATGGCCGAATGGCTGAAGACCTGGGGCACCCCCGATCGCAAGCCCCTGCCCCCCGAATGGCTCAAAT
AA

Structures

Toxin

• AlphaFold DB: A0A0C9M624