Detailed information of TA system TA037600

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 2974064..2974623
• Replicon: chromosome
• Accession: NZ_AP023323
• Organism: Sphingomonas paucimobilis strain Kira

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SPKIRA_RS13835
• Protein ID: WP_047866838.1
• Coordinates: 2974064..2974357 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: SPKIRA_RS13840
• Protein ID: WP_047866857.1
• Coordinates: 2974354..2974623 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SPKIRA_RS13815	2971023..2971889	-	867	WP_007404849.1	peptidylprolyl isomerase	-
SPKIRA_RS13825	2972035..2973675	-	1641	Protein_2715	recombinase family protein	-
SPKIRA_RS13830	2973694..2973948	-	255	WP_047866839.1	hypothetical protein	-
SPKIRA_RS13835	2974064..2974357	-	294	WP_047866838.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SPKIRA_RS13840	2974354..2974623	-	270	WP_047866857.1	ribbon-helix-helix domain-containing protein	Antitoxin
SPKIRA_RS13845	2975087..2977147	+	2061	WP_082132049.1	ParB/RepB/Spo0J family partition protein	-
SPKIRA_RS13850	2977814..2978113	+	300	WP_047866855.1	DUF736 domain-containing protein	-
SPKIRA_RS13855	2978399..2979241	+	843	WP_047866837.1	DUF945 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-45)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11460.11 Da
• Isoelectric Point: 7.2779

>T37600 WP_047866838.1 NZ_AP023323:c2974357-2974064 [Sphingomonas paucimobilis]
MKIKWTGKASSDLVRLHEHLRPVAPEAAARVVQQLSRAPDRLLDYPRIGEKLDAYEPREVRRIIVGNYELRYEIADATIF
ILRLWHCREERSFESDE

Nucleotide

• Length: 294 bp

>T37600 NZ_AP023323:c2974357-2974064 [Sphingomonas paucimobilis]
ATGAAGATCAAGTGGACCGGCAAGGCATCCTCGGATCTTGTGCGGCTGCACGAGCATCTGCGTCCGGTTGCCCCCGAGGC
GGCGGCGCGAGTCGTGCAGCAGCTTTCGCGCGCGCCGGATCGCCTGCTCGACTATCCCCGGATCGGCGAGAAGCTGGACG
CCTACGAACCGCGCGAGGTCCGACGCATCATCGTCGGCAACTATGAGCTGCGCTACGAGATCGCGGATGCGACGATCTTC
ATCCTGCGCCTGTGGCATTGCCGCGAGGAGCGCAGCTTCGAGTCGGACGAGTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9944.33 Da
• Isoelectric Point: 4.8380

>AT37600 WP_047866857.1 NZ_AP023323:c2974623-2974354 [Sphingomonas paucimobilis]
MATETKVMTAHVPLQLAEKVEAMASRLERSRGWVMKQALAAWVDQEEERHRMTLEALEDVDAGRVIDHQAVRAWADSLGT
DNPLPPPLA

Nucleotide

• Length: 270 bp

>AT37600 NZ_AP023323:c2974623-2974354 [Sphingomonas paucimobilis]
ATGGCTACTGAGACGAAAGTAATGACCGCACACGTCCCGCTACAACTCGCGGAGAAGGTCGAAGCGATGGCCTCGCGGCT
TGAGCGTTCGCGCGGCTGGGTAATGAAGCAGGCGCTCGCCGCTTGGGTCGATCAGGAGGAGGAGCGTCACAGGATGACGC
TCGAAGCGCTGGAAGATGTCGATGCCGGGCGCGTGATCGACCATCAGGCTGTGCGCGCATGGGCGGACAGCCTCGGCACC
GACAACCCGCTTCCGCCGCCCTTGGCATGA