Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4398668..4399449 Replicon chromosome
Accession NZ_AP023319
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4741

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag K5619_RS21485 Protein ID WP_000626099.1
Coordinates 4398668..4399159 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag K5619_RS21490 Protein ID WP_001110452.1
Coordinates 4399156..4399449 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5619_RS21445 (4393854) 4393854..4394096 - 243 WP_197603740.1 hypothetical protein -
K5619_RS21450 (4394093) 4394093..4394449 - 357 WP_033567083.1 hypothetical protein -
K5619_RS21455 (4394446) 4394446..4395318 - 873 WP_033567082.1 ParA family protein -
K5619_RS21460 (4395509) 4395509..4395586 - 78 Protein_4215 helix-turn-helix domain-containing protein -
K5619_RS21465 (4395677) 4395677..4396009 - 333 WP_001165471.1 MerR family transcriptional regulator -
K5619_RS21470 (4396081) 4396081..4396458 + 378 WP_000916345.1 EthD family reductase -
K5619_RS21475 (4397491) 4397491..4397565 + 75 Protein_4218 porin family protein -
K5619_RS21480 (4397668) 4397668..4398420 + 753 WP_000842434.1 non-specific acid phosphatase -
K5619_RS21485 (4398668) 4398668..4399159 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
K5619_RS21490 (4399156) 4399156..4399449 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
K5619_RS21495 (4399766) 4399766..4399987 + 222 WP_001576552.1 hypothetical protein -
K5619_RS21500 (4400252) 4400252..4401127 + 876 WP_000921674.1 AraC family transcriptional regulator -
K5619_RS21505 (4401124) 4401124..4401411 + 288 WP_001269916.1 transcriptional regulator RtsB -
K5619_RS21510 (4401434) 4401434..4401649 + 216 WP_001595136.1 hypothetical protein -
K5619_RS21515 (4401657) 4401657..4401926 + 270 WP_010989096.1 hypothetical protein -
K5619_RS21520 (4402220) 4402220..4403125 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T37597 WP_000626099.1 NZ_AP023319:c4399159-4398668 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T37597 NZ_AP023319:c4399159-4398668 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT37597 WP_001110452.1 NZ_AP023319:c4399449-4399156 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT37597 NZ_AP023319:c4399449-4399156 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References