Detailed information of TA system TA037595

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpAB/BrnT-BrnA
• Location: 4094329..4094905
• Replicon: chromosome
• Accession: NZ_AP023319
• Organism: Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4741

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: M7RG88
• Locus tag: K5619_RS19980
• Protein ID: WP_001131963.1
• Coordinates: 4094618..4094905 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: shpB
• Uniprot ID: -
• Locus tag: K5619_RS19975
• Protein ID: WP_221077349.1
• Coordinates: 4094329..4094631 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5619_RS19960 (4090839)	4090839..4092989	+	2151	WP_000379927.1	pyruvate/proton symporter BtsT	-
K5619_RS19965 (4093084)	4093084..4093287	+	204	WP_000460616.1	YbdD/YjiX family protein	-
K5619_RS19970 (4093298)	4093298..4094254	+	957	WP_000187839.1	GTPase	-
K5619_RS19975 (4094329)	4094329..4094631	-	303	WP_221077349.1	BrnA antitoxin family protein	Antitoxin
K5619_RS19980 (4094618)	4094618..4094905	-	288	WP_001131963.1	BrnT family toxin	Toxin
K5619_RS19985 (4095174)	4095174..4096088	-	915	WP_000290512.1	restriction endonuclease	-
K5619_RS19990 (4096286)	4096286..4099795	+	3510	WP_001043484.1	type I restriction-modification system endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (7-88)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (37-93)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11294.80 Da
• Isoelectric Point: 9.5894

>T37595 WP_001131963.1 NZ_AP023319:c4094905-4094618 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Nucleotide

• Length: 288 bp

>T37595 NZ_AP023319:c4094905-4094618 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11359.93 Da
• Isoelectric Point: 10.1293

>AT37595 WP_221077349.1 NZ_AP023319:c4094631-4094329 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MSMVKHKRGNASALSAQHEAEVKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Nucleotide

• Length: 303 bp

>AT37595 NZ_AP023319:c4094631-4094329 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAAGTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Structures

Toxin

• PDB: 7VD7