37591

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3475415..3476035 Replicon chromosome
Accession NZ_AP023319
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4741

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag K5619_RS17115 Protein ID WP_001280991.1
Coordinates 3475817..3476035 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag K5619_RS17110 Protein ID WP_000344807.1
Coordinates 3475415..3475789 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5619_RS17100 (3470554) 3470554..3471747 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K5619_RS17105 (3471770) 3471770..3474919 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
K5619_RS17110 (3475415) 3475415..3475789 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
K5619_RS17115 (3475817) 3475817..3476035 + 219 WP_001280991.1 HHA domain-containing protein Toxin
K5619_RS17120 (3476214) 3476214..3476765 + 552 WP_001278792.1 maltose O-acetyltransferase -
K5619_RS17125 (3476882) 3476882..3477352 + 471 WP_000136181.1 YlaC family protein -
K5619_RS17130 (3477408) 3477408..3477548 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
K5619_RS17135 (3477554) 3477554..3477814 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
K5619_RS17140 (3478039) 3478039..3479589 + 1551 WP_000213139.1 EAL domain-containing protein -
K5619_RS17150 (3479820) 3479820..3480209 + 390 WP_000961285.1 MGMT family protein -
K5619_RS17155 (3480242) 3480242..3480811 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T37591 WP_001280991.1 NZ_AP023319:3475817-3476035 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T37591 NZ_AP023319:3475817-3476035 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT37591 WP_000344807.1 NZ_AP023319:3475415-3475789 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT37591 NZ_AP023319:3475415-3475789 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References