Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 206630..207390 Replicon chromosome
Accession NZ_AP023319
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4741

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag K5619_RS00970 Protein ID WP_000533909.1
Coordinates 206905..207390 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag K5619_RS00965 Protein ID WP_000965886.1
Coordinates 206630..206917 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5619_RS00940 (201925) 201925..202227 + 303 WP_000605590.1 YsaB family lipoprotein -
K5619_RS00945 (202366) 202366..203277 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
K5619_RS00950 (203287) 203287..205356 + 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
K5619_RS00955 (205538) 205538..205813 + 276 Protein_189 IS3 family transposase -
K5619_RS00960 (205985) 205985..206452 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
K5619_RS00965 (206630) 206630..206917 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
K5619_RS00970 (206905) 206905..207390 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
K5619_RS00975 (207762) 207762..208301 - 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
K5619_RS00980 (208475) 208475..208687 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
K5619_RS00985 (208976) 208976..209266 - 291 WP_000455790.1 HTH-type transcriptional regulator -
K5619_RS00990 (209705) 209705..210415 + 711 WP_000190524.1 DUF3053 domain-containing protein -
K5619_RS00995 (210465) 210465..211439 - 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
K5619_RS01000 (211658) 211658..212320 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T37576 WP_000533909.1 NZ_AP023319:206905-207390 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T37576 NZ_AP023319:206905-207390 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT37576 WP_000965886.1 NZ_AP023319:206630-206917 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT37576 NZ_AP023319:206630-206917 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References