Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4462519..4463300 Replicon chromosome
Accession NZ_AP023317
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4681

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag K5693_RS21900 Protein ID WP_000626099.1
Coordinates 4462519..4463010 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag K5693_RS21905 Protein ID WP_001110452.1
Coordinates 4463007..4463300 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5693_RS21860 (4457705) 4457705..4457947 - 243 WP_197603740.1 hypothetical protein -
K5693_RS21865 (4457944) 4457944..4458300 - 357 WP_033567083.1 hypothetical protein -
K5693_RS21870 (4458297) 4458297..4459169 - 873 WP_033567082.1 ParA family protein -
K5693_RS21875 (4459360) 4459360..4459437 - 78 Protein_4294 helix-turn-helix domain-containing protein -
K5693_RS21880 (4459528) 4459528..4459860 - 333 WP_001165471.1 MerR family transcriptional regulator -
K5693_RS21885 (4459932) 4459932..4460309 + 378 WP_000916345.1 EthD family reductase -
K5693_RS21890 (4461342) 4461342..4461416 + 75 Protein_4297 porin family protein -
K5693_RS21895 (4461519) 4461519..4462271 + 753 WP_000842434.1 non-specific acid phosphatase -
K5693_RS21900 (4462519) 4462519..4463010 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
K5693_RS21905 (4463007) 4463007..4463300 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
K5693_RS21910 (4463617) 4463617..4463838 + 222 WP_001576552.1 hypothetical protein -
K5693_RS21915 (4464103) 4464103..4464978 + 876 WP_000921674.1 AraC family transcriptional regulator -
K5693_RS21920 (4464975) 4464975..4465262 + 288 WP_001269916.1 transcriptional regulator RtsB -
K5693_RS21925 (4465285) 4465285..4465500 + 216 WP_001595136.1 hypothetical protein -
K5693_RS21930 (4465508) 4465508..4465777 + 270 WP_010989096.1 hypothetical protein -
K5693_RS21935 (4466071) 4466071..4466976 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T37572 WP_000626099.1 NZ_AP023317:c4463010-4462519 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T37572 NZ_AP023317:c4463010-4462519 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT37572 WP_001110452.1 NZ_AP023317:c4463300-4463007 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT37572 NZ_AP023317:c4463300-4463007 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References