Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4158181..4158757 Replicon chromosome
Accession NZ_AP023317
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4681

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag K5693_RS20395 Protein ID WP_001131963.1
Coordinates 4158470..4158757 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag K5693_RS20390 Protein ID WP_000063142.1
Coordinates 4158181..4158483 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5693_RS20375 (4154691) 4154691..4156841 + 2151 WP_000379927.1 pyruvate/proton symporter BtsT -
K5693_RS20380 (4156936) 4156936..4157139 + 204 WP_000460616.1 YbdD/YjiX family protein -
K5693_RS20385 (4157150) 4157150..4158106 + 957 WP_000187839.1 GTPase -
K5693_RS20390 (4158181) 4158181..4158483 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
K5693_RS20395 (4158470) 4158470..4158757 - 288 WP_001131963.1 BrnT family toxin Toxin
K5693_RS20400 (4159026) 4159026..4159940 - 915 WP_000290512.1 restriction endonuclease -
K5693_RS20405 (4160138) 4160138..4163647 + 3510 WP_001043484.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T37570 WP_001131963.1 NZ_AP023317:c4158757-4158470 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T37570 NZ_AP023317:c4158757-4158470 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT37570 WP_000063142.1 NZ_AP023317:c4158483-4158181 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT37570 NZ_AP023317:c4158483-4158181 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References