Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 871180..871840 Replicon chromosome
Accession NZ_AP023317
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4681

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag K5693_RS04245 Protein ID WP_000244756.1
Coordinates 871427..871840 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag K5693_RS04240 Protein ID WP_000351186.1
Coordinates 871180..871446 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5693_RS04220 (867108) 867108..868541 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
K5693_RS04225 (868700) 868700..869011 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
K5693_RS04230 (869175) 869175..869834 + 660 WP_000250289.1 hemolysin III family protein -
K5693_RS04235 (869950) 869950..870930 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
K5693_RS04240 (871180) 871180..871446 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
K5693_RS04245 (871427) 871427..871840 + 414 WP_000244756.1 protein YgfX Toxin
K5693_RS04250 (871893) 871893..872414 - 522 WP_001055885.1 flavodoxin FldB -
K5693_RS04255 (872527) 872527..873423 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
K5693_RS04260 (873447) 873447..874160 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K5693_RS04265 (874166) 874166..875899 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T37554 WP_000244756.1 NZ_AP023317:871427-871840 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T37554 NZ_AP023317:871427-871840 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT37554 WP_000351186.1 NZ_AP023317:871180-871446 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT37554 NZ_AP023317:871180-871446 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References