Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4399540..4400321 Replicon chromosome
Accession NZ_AP023315
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4614

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag K5684_RS21500 Protein ID WP_000626099.1
Coordinates 4399540..4400031 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag K5684_RS21505 Protein ID WP_001110452.1
Coordinates 4400028..4400321 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5684_RS21460 (4394726) 4394726..4394968 - 243 WP_197603740.1 hypothetical protein -
K5684_RS21465 (4394965) 4394965..4395321 - 357 WP_033567083.1 hypothetical protein -
K5684_RS21470 (4395318) 4395318..4396190 - 873 WP_033567082.1 ParA family protein -
K5684_RS21475 (4396381) 4396381..4396458 - 78 Protein_4221 helix-turn-helix domain-containing protein -
K5684_RS21480 (4396549) 4396549..4396881 - 333 WP_001165471.1 MerR family transcriptional regulator -
K5684_RS21485 (4396953) 4396953..4397330 + 378 WP_000916345.1 EthD family reductase -
K5684_RS21490 (4398363) 4398363..4398437 + 75 Protein_4224 porin family protein -
K5684_RS21495 (4398540) 4398540..4399292 + 753 WP_000842434.1 non-specific acid phosphatase -
K5684_RS21500 (4399540) 4399540..4400031 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
K5684_RS21505 (4400028) 4400028..4400321 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
K5684_RS21510 (4400638) 4400638..4400859 + 222 WP_001576552.1 hypothetical protein -
K5684_RS21515 (4401124) 4401124..4401999 + 876 WP_000921674.1 AraC family transcriptional regulator -
K5684_RS21520 (4401996) 4401996..4402283 + 288 WP_001269916.1 transcriptional regulator RtsB -
K5684_RS21525 (4402306) 4402306..4402521 + 216 WP_001595136.1 hypothetical protein -
K5684_RS21530 (4402529) 4402529..4402798 + 270 WP_010989096.1 hypothetical protein -
K5684_RS21535 (4403092) 4403092..4403997 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T37547 WP_000626099.1 NZ_AP023315:c4400031-4399540 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T37547 NZ_AP023315:c4400031-4399540 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT37547 WP_001110452.1 NZ_AP023315:c4400321-4400028 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT37547 NZ_AP023315:c4400321-4400028 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References