Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4189462..4189978 Replicon chromosome
Accession NZ_AP023315
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4614

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag K5684_RS20395 Protein ID WP_000220578.1
Coordinates 4189462..4189746 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag K5684_RS20400 Protein ID WP_000212724.1
Coordinates 4189736..4189978 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5684_RS20380 (4184674) 4184674..4186326 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
K5684_RS20385 (4186735) 4186735..4188873 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
K5684_RS20390 (4188994) 4188994..4189458 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K5684_RS20395 (4189462) 4189462..4189746 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K5684_RS20400 (4189736) 4189736..4189978 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K5684_RS20405 (4190056) 4190056..4191969 - 1914 WP_001212137.1 BglG family transcription antiterminator -
K5684_RS20410 (4191986) 4191986..4192726 - 741 WP_000779263.1 KDGP aldolase family protein -
K5684_RS20415 (4192723) 4192723..4193841 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
K5684_RS20420 (4193825) 4193825..4194958 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T37546 WP_000220578.1 NZ_AP023315:c4189746-4189462 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T37546 NZ_AP023315:c4189746-4189462 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT37546 WP_000212724.1 NZ_AP023315:c4189978-4189736 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT37546 NZ_AP023315:c4189978-4189736 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References