Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 30829..31472 Replicon plasmid L-4605 strain 4[5]12:i:-
Accession NZ_AP023314
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4605

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag K5670_RS24020 Protein ID WP_001044768.1
Coordinates 30829..31245 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag K5670_RS24025 Protein ID WP_001261287.1
Coordinates 31242..31472 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5670_RS24005 (26133) 26133..27026 - 894 WP_001553853.1 S-4TM family putative pore-forming effector -
K5670_RS24010 (27069) 27069..28064 - 996 WP_000246636.1 hypothetical protein -
K5670_RS24015 (28529) 28529..30667 + 2139 WP_039002805.1 AAA family ATPase -
K5670_RS24020 (30829) 30829..31245 - 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
K5670_RS24025 (31242) 31242..31472 - 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K5670_RS24615 (31778) 31778..32326 + 549 WP_039002808.1 hypothetical protein -
K5670_RS24620 (32378) 32378..33208 + 831 WP_223201786.1 hypothetical protein -
K5670_RS24625 (33259) 33259..34896 + 1638 WP_223201785.1 hypothetical protein -
K5670_RS24035 (35159) 35159..36292 + 1134 WP_000545983.1 DUF3800 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mcr-3.1 / aac(3)-IId / blaTEM-1B / sul3 - 1..99131 99131


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T37522 WP_001044768.1 NZ_AP023314:c31245-30829 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

>T37522 NZ_AP023314:c31245-30829 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT37522 WP_001261287.1 NZ_AP023314:c31472-31242 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT37522 NZ_AP023314:c31472-31242 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References