Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4391656..4392437 Replicon chromosome
Accession NZ_AP023313
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4605

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag K5670_RS21440 Protein ID WP_000626099.1
Coordinates 4391656..4392147 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag K5670_RS21445 Protein ID WP_001110452.1
Coordinates 4392144..4392437 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5670_RS21400 (4386842) 4386842..4387084 - 243 WP_197603740.1 hypothetical protein -
K5670_RS21405 (4387081) 4387081..4387437 - 357 WP_033567083.1 hypothetical protein -
K5670_RS21410 (4387434) 4387434..4388306 - 873 WP_033567082.1 ParA family protein -
K5670_RS21415 (4388497) 4388497..4388574 - 78 Protein_4206 helix-turn-helix domain-containing protein -
K5670_RS21420 (4388665) 4388665..4388997 - 333 WP_001165471.1 MerR family transcriptional regulator -
K5670_RS21425 (4389069) 4389069..4389446 + 378 WP_000916345.1 EthD family reductase -
K5670_RS21430 (4390479) 4390479..4390553 + 75 Protein_4209 porin family protein -
K5670_RS21435 (4390656) 4390656..4391408 + 753 WP_000842434.1 non-specific acid phosphatase -
K5670_RS21440 (4391656) 4391656..4392147 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
K5670_RS21445 (4392144) 4392144..4392437 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
K5670_RS21450 (4392754) 4392754..4392975 + 222 WP_001576552.1 hypothetical protein -
K5670_RS21455 (4393240) 4393240..4394115 + 876 WP_000921674.1 AraC family transcriptional regulator -
K5670_RS21460 (4394112) 4394112..4394399 + 288 WP_001269916.1 transcriptional regulator RtsB -
K5670_RS21465 (4394422) 4394422..4394637 + 216 WP_001595136.1 hypothetical protein -
K5670_RS21470 (4394645) 4394645..4394914 + 270 WP_010989096.1 hypothetical protein -
K5670_RS21475 (4395208) 4395208..4396113 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T37518 WP_000626099.1 NZ_AP023313:c4392147-4391656 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T37518 NZ_AP023313:c4392147-4391656 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT37518 WP_001110452.1 NZ_AP023313:c4392437-4392144 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT37518 NZ_AP023313:c4392437-4392144 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References