Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3468403..3469023 | Replicon | chromosome |
Accession | NZ_AP023313 | ||
Organism | Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4605 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | V1H8E6 |
Locus tag | K5670_RS17070 | Protein ID | WP_001280991.1 |
Coordinates | 3468805..3469023 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | V1H4V6 |
Locus tag | K5670_RS17065 | Protein ID | WP_000344807.1 |
Coordinates | 3468403..3468777 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K5670_RS17055 (3463542) | 3463542..3464735 | + | 1194 | WP_001039202.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
K5670_RS17060 (3464758) | 3464758..3467907 | + | 3150 | WP_001132508.1 | efflux RND transporter permease AcrB | - |
K5670_RS17065 (3468403) | 3468403..3468777 | + | 375 | WP_000344807.1 | Hha toxicity modulator TomB | Antitoxin |
K5670_RS17070 (3468805) | 3468805..3469023 | + | 219 | WP_001280991.1 | HHA domain-containing protein | Toxin |
K5670_RS17075 (3469202) | 3469202..3469753 | + | 552 | WP_001278792.1 | maltose O-acetyltransferase | - |
K5670_RS17080 (3469870) | 3469870..3470340 | + | 471 | WP_000136181.1 | YlaC family protein | - |
K5670_RS17085 (3470396) | 3470396..3470536 | - | 141 | WP_001197749.1 | type B 50S ribosomal protein L36 | - |
K5670_RS17090 (3470542) | 3470542..3470802 | - | 261 | WP_000801415.1 | type B 50S ribosomal protein L31 | - |
K5670_RS17095 (3471026) | 3471026..3472576 | + | 1551 | WP_000213139.1 | EAL domain-containing protein | - |
K5670_RS17105 (3472807) | 3472807..3473196 | + | 390 | WP_000961285.1 | MGMT family protein | - |
K5670_RS17110 (3473229) | 3473229..3473798 | - | 570 | WP_000779803.1 | YbaY family lipoprotein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8613.97 Da Isoelectric Point: 8.9008
>T37512 WP_001280991.1 NZ_AP023313:3468805-3469023 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
>T37512 NZ_AP023313:3468805-3469023 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14453.27 Da Isoelectric Point: 5.1444
>AT37512 WP_000344807.1 NZ_AP023313:3468403-3468777 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
Download Length: 375 bp
>AT37512 NZ_AP023313:3468403-3468777 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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