Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4397870..4398651 Replicon chromosome
Accession NZ_AP023311
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4596

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag K5674_RS21490 Protein ID WP_000626099.1
Coordinates 4397870..4398361 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag K5674_RS21495 Protein ID WP_001110452.1
Coordinates 4398358..4398651 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5674_RS21450 (4393056) 4393056..4393298 - 243 WP_197603740.1 hypothetical protein -
K5674_RS21455 (4393295) 4393295..4393651 - 357 WP_033567083.1 hypothetical protein -
K5674_RS21460 (4393648) 4393648..4394520 - 873 WP_033567082.1 ParA family protein -
K5674_RS21465 (4394711) 4394711..4394788 - 78 Protein_4216 helix-turn-helix domain-containing protein -
K5674_RS21470 (4394879) 4394879..4395211 - 333 WP_001165471.1 MerR family transcriptional regulator -
K5674_RS21475 (4395283) 4395283..4395660 + 378 WP_000916345.1 EthD family reductase -
K5674_RS21480 (4396693) 4396693..4396767 + 75 Protein_4219 porin family protein -
K5674_RS21485 (4396870) 4396870..4397622 + 753 WP_000842434.1 non-specific acid phosphatase -
K5674_RS21490 (4397870) 4397870..4398361 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
K5674_RS21495 (4398358) 4398358..4398651 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
K5674_RS21500 (4398968) 4398968..4399189 + 222 WP_001576552.1 hypothetical protein -
K5674_RS21505 (4399454) 4399454..4400329 + 876 WP_000921674.1 AraC family transcriptional regulator -
K5674_RS21510 (4400326) 4400326..4400613 + 288 WP_001269916.1 transcriptional regulator RtsB -
K5674_RS21515 (4400636) 4400636..4400851 + 216 WP_001595136.1 hypothetical protein -
K5674_RS21520 (4400859) 4400859..4401128 + 270 WP_010989096.1 hypothetical protein -
K5674_RS21525 (4401422) 4401422..4402327 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T37494 WP_000626099.1 NZ_AP023311:c4398361-4397870 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T37494 NZ_AP023311:c4398361-4397870 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT37494 WP_001110452.1 NZ_AP023311:c4398651-4398358 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT37494 NZ_AP023311:c4398651-4398358 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References