Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 838430..839090 Replicon chromosome
Accession NZ_AP023311
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4596

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag K5674_RS04040 Protein ID WP_000244756.1
Coordinates 838677..839090 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag K5674_RS04035 Protein ID WP_000351186.1
Coordinates 838430..838696 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5674_RS04015 (834358) 834358..835791 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
K5674_RS04020 (835950) 835950..836261 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
K5674_RS04025 (836425) 836425..837084 + 660 WP_000250289.1 hemolysin III family protein -
K5674_RS04030 (837200) 837200..838180 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
K5674_RS04035 (838430) 838430..838696 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
K5674_RS04040 (838677) 838677..839090 + 414 WP_000244756.1 protein YgfX Toxin
K5674_RS04045 (839143) 839143..839664 - 522 WP_001055885.1 flavodoxin FldB -
K5674_RS04050 (839777) 839777..840673 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
K5674_RS04055 (840697) 840697..841410 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K5674_RS04060 (841416) 841416..843149 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T37476 WP_000244756.1 NZ_AP023311:838677-839090 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T37476 NZ_AP023311:838677-839090 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT37476 WP_000351186.1 NZ_AP023311:838430-838696 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT37476 NZ_AP023311:838430-838696 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References