Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4372170..4372951 Replicon chromosome
Accession NZ_AP023309
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4578

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag K5680_RS21310 Protein ID WP_000626099.1
Coordinates 4372170..4372661 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag K5680_RS21315 Protein ID WP_001110452.1
Coordinates 4372658..4372951 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5680_RS21270 (4367356) 4367356..4367598 - 243 WP_197603740.1 hypothetical protein -
K5680_RS21275 (4367595) 4367595..4367951 - 357 WP_033567083.1 hypothetical protein -
K5680_RS21280 (4367948) 4367948..4368820 - 873 WP_033567082.1 ParA family protein -
K5680_RS21285 (4369011) 4369011..4369088 - 78 Protein_4181 helix-turn-helix domain-containing protein -
K5680_RS21290 (4369179) 4369179..4369511 - 333 WP_001165471.1 MerR family transcriptional regulator -
K5680_RS21295 (4369583) 4369583..4369960 + 378 WP_000916345.1 EthD family reductase -
K5680_RS21300 (4370993) 4370993..4371067 + 75 Protein_4184 porin family protein -
K5680_RS21305 (4371170) 4371170..4371922 + 753 WP_000842434.1 non-specific acid phosphatase -
K5680_RS21310 (4372170) 4372170..4372661 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
K5680_RS21315 (4372658) 4372658..4372951 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
K5680_RS21320 (4373268) 4373268..4373489 + 222 WP_001576552.1 hypothetical protein -
K5680_RS21325 (4373754) 4373754..4374629 + 876 WP_000921674.1 AraC family transcriptional regulator -
K5680_RS21330 (4374626) 4374626..4374913 + 288 WP_001269916.1 transcriptional regulator RtsB -
K5680_RS21335 (4374936) 4374936..4375151 + 216 WP_001595136.1 hypothetical protein -
K5680_RS21340 (4375159) 4375159..4375428 + 270 WP_010989096.1 hypothetical protein -
K5680_RS21345 (4375722) 4375722..4376627 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T37469 WP_000626099.1 NZ_AP023309:c4372661-4372170 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T37469 NZ_AP023309:c4372661-4372170 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT37469 WP_001110452.1 NZ_AP023309:c4372951-4372658 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT37469 NZ_AP023309:c4372951-4372658 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References