Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4162092..4162608 Replicon chromosome
Accession NZ_AP023309
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4578

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag K5680_RS20205 Protein ID WP_000220578.1
Coordinates 4162092..4162376 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag K5680_RS20210 Protein ID WP_000212724.1
Coordinates 4162366..4162608 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5680_RS20190 (4157304) 4157304..4158956 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
K5680_RS20195 (4159365) 4159365..4161503 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
K5680_RS20200 (4161624) 4161624..4162088 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K5680_RS20205 (4162092) 4162092..4162376 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K5680_RS20210 (4162366) 4162366..4162608 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K5680_RS20215 (4162686) 4162686..4164599 - 1914 WP_001212137.1 BglG family transcription antiterminator -
K5680_RS20220 (4164616) 4164616..4165356 - 741 WP_000779263.1 KDGP aldolase family protein -
K5680_RS20225 (4165353) 4165353..4166471 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
K5680_RS20230 (4166455) 4166455..4167588 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T37468 WP_000220578.1 NZ_AP023309:c4162376-4162092 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T37468 NZ_AP023309:c4162376-4162092 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT37468 WP_000212724.1 NZ_AP023309:c4162608-4162366 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT37468 NZ_AP023309:c4162608-4162366 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References