Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 52912..53447 Replicon plasmid L-4567 strain 4[5]12:i:-
Accession NZ_AP023307
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4567

Toxin (Protein)


Gene name relE Uniprot ID Q3YTD6
Locus tag K5646_RS24200 Protein ID WP_000222766.1
Coordinates 52912..53199 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0VIP2
Locus tag K5646_RS24205 Protein ID WP_001132900.1
Coordinates 53196..53447 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5646_RS24160 (47919) 47919..48233 + 315 WP_039026396.1 transposase -
K5646_RS24165 (48269) 48269..49051 + 783 WP_223936907.1 IS3 family transposase -
K5646_RS24170 (49035) 49035..49256 + 222 WP_226909166.1 hypothetical protein -
K5646_RS24175 (49576) 49576..49962 - 387 WP_063102497.1 bleomycin binding protein -
K5646_RS24180 (50156) 50156..50860 - 705 WP_001067858.1 IS6-like element IS26 family transposase -
K5646_RS24890 (50921) 50921..51001 + 81 Protein_61 MerR family transcriptional regulator -
K5646_RS24185 (51035) 51035..52081 + 1047 Protein_62 Tn3 family transposase -
K5646_RS24190 (52115) 52115..52615 + 501 Protein_63 Tn3 family transposase -
K5646_RS24195 (52649) 52649..52837 + 189 Protein_64 IS3 family transposase -
K5646_RS24200 (52912) 52912..53199 - 288 WP_000222766.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K5646_RS24205 (53196) 53196..53447 - 252 WP_001132900.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K5646_RS24210 (54413) 54413..55270 - 858 WP_039002220.1 incFII family plasmid replication initiator RepA -
K5646_RS24215 (55263) 55263..55337 - 75 WP_061357229.1 RepA leader peptide Tap -
K5646_RS24220 (55569) 55569..55826 - 258 WP_001541895.1 replication regulatory protein RepA -
K5646_RS24225 (56094) 56094..56243 - 150 WP_001312851.1 Hok/Gef family protein -
- (56287) 56287..56348 + 62 NuclAT_1 - -
- (56287) 56287..56348 + 62 NuclAT_1 - -
- (56287) 56287..56348 + 62 NuclAT_1 - -
- (56287) 56287..56348 + 62 NuclAT_1 - -
K5646_RS24230 (56690) 56690..56902 - 213 WP_001541896.1 ANR family transcriptional regulator -
K5646_RS24235 (57037) 57037..57597 - 561 WP_000139310.1 fertility inhibition protein FinO -
K5646_RS24240 (57652) 57652..58395 - 744 WP_039002216.1 conjugal transfer pilus acetylase TraX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(M) / ant(3'')-Ia / cmlA1 / aadA2 / dfrA12 / floR / sul2 / tet(A) / sul3 / blaTEM-1B / aac(3)-IId / mcr-3.1 - 1..131843 131843


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11147.23 Da        Isoelectric Point: 10.5832

>T37439 WP_000222766.1 NZ_AP023307:c53199-52912 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MTYTVKFRDDALKEWLKLDKTIQQQFVKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR

Download         Length: 288 bp

>T37439 NZ_AP023307:c53199-52912 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGACTTATACGGTAAAATTCAGGGATGATGCGCTCAAGGAATGGCTGAAACTGGATAAGACCATTCAACAACAGTTTGT
GAAAAAACTAAAAAAATGCAGCGAAAATCCTCATATACCGTCAGCAAAACTAAGAGGGCTAAAGGATTGCTACAAAATTA
AACTACGTGCATCGGGATTTCGTCTGGTTTATCAGGTGATTGACGATATGTTAATTATTGCGGTTGTTGCGGTAGGAAAA
CGAGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9211.41 Da        Isoelectric Point: 4.0780

>AT37439 WP_001132900.1 NZ_AP023307:c53447-53196 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp

>AT37439 NZ_AP023307:c53447-53196 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTACCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCTGAACTGTATGAAAGGATGC
TTGATGCTCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTAGAC
AGTTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDZ2

Antitoxin

Source ID Structure
AlphaFold DB V0VIP2

References