Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 52912..53447 | Replicon | plasmid L-4567 strain 4[5]12:i:- |
| Accession | NZ_AP023307 | ||
| Organism | Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4567 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | Q3YTD6 |
| Locus tag | K5646_RS24200 | Protein ID | WP_000222766.1 |
| Coordinates | 52912..53199 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | V0VIP2 |
| Locus tag | K5646_RS24205 | Protein ID | WP_001132900.1 |
| Coordinates | 53196..53447 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K5646_RS24160 (47919) | 47919..48233 | + | 315 | WP_039026396.1 | transposase | - |
| K5646_RS24165 (48269) | 48269..49051 | + | 783 | WP_223936907.1 | IS3 family transposase | - |
| K5646_RS24170 (49035) | 49035..49256 | + | 222 | WP_226909166.1 | hypothetical protein | - |
| K5646_RS24175 (49576) | 49576..49962 | - | 387 | WP_063102497.1 | bleomycin binding protein | - |
| K5646_RS24180 (50156) | 50156..50860 | - | 705 | WP_001067858.1 | IS6-like element IS26 family transposase | - |
| K5646_RS24890 (50921) | 50921..51001 | + | 81 | Protein_61 | MerR family transcriptional regulator | - |
| K5646_RS24185 (51035) | 51035..52081 | + | 1047 | Protein_62 | Tn3 family transposase | - |
| K5646_RS24190 (52115) | 52115..52615 | + | 501 | Protein_63 | Tn3 family transposase | - |
| K5646_RS24195 (52649) | 52649..52837 | + | 189 | Protein_64 | IS3 family transposase | - |
| K5646_RS24200 (52912) | 52912..53199 | - | 288 | WP_000222766.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K5646_RS24205 (53196) | 53196..53447 | - | 252 | WP_001132900.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| K5646_RS24210 (54413) | 54413..55270 | - | 858 | WP_039002220.1 | incFII family plasmid replication initiator RepA | - |
| K5646_RS24215 (55263) | 55263..55337 | - | 75 | WP_061357229.1 | RepA leader peptide Tap | - |
| K5646_RS24220 (55569) | 55569..55826 | - | 258 | WP_001541895.1 | replication regulatory protein RepA | - |
| K5646_RS24225 (56094) | 56094..56243 | - | 150 | WP_001312851.1 | Hok/Gef family protein | - |
| - (56287) | 56287..56348 | + | 62 | NuclAT_1 | - | - |
| - (56287) | 56287..56348 | + | 62 | NuclAT_1 | - | - |
| - (56287) | 56287..56348 | + | 62 | NuclAT_1 | - | - |
| - (56287) | 56287..56348 | + | 62 | NuclAT_1 | - | - |
| K5646_RS24230 (56690) | 56690..56902 | - | 213 | WP_001541896.1 | ANR family transcriptional regulator | - |
| K5646_RS24235 (57037) | 57037..57597 | - | 561 | WP_000139310.1 | fertility inhibition protein FinO | - |
| K5646_RS24240 (57652) | 57652..58395 | - | 744 | WP_039002216.1 | conjugal transfer pilus acetylase TraX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | tet(M) / ant(3'')-Ia / cmlA1 / aadA2 / dfrA12 / floR / sul2 / tet(A) / sul3 / blaTEM-1B / aac(3)-IId / mcr-3.1 | - | 1..131843 | 131843 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11147.23 Da Isoelectric Point: 10.5832
>T37439 WP_000222766.1 NZ_AP023307:c53199-52912 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MTYTVKFRDDALKEWLKLDKTIQQQFVKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR
MTYTVKFRDDALKEWLKLDKTIQQQFVKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYNLASERMR
Download Length: 288 bp
>T37439 NZ_AP023307:c53199-52912 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGACTTATACGGTAAAATTCAGGGATGATGCGCTCAAGGAATGGCTGAAACTGGATAAGACCATTCAACAACAGTTTGT
GAAAAAACTAAAAAAATGCAGCGAAAATCCTCATATACCGTCAGCAAAACTAAGAGGGCTAAAGGATTGCTACAAAATTA
AACTACGTGCATCGGGATTTCGTCTGGTTTATCAGGTGATTGACGATATGTTAATTATTGCGGTTGTTGCGGTAGGAAAA
CGAGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG
ATGACTTATACGGTAAAATTCAGGGATGATGCGCTCAAGGAATGGCTGAAACTGGATAAGACCATTCAACAACAGTTTGT
GAAAAAACTAAAAAAATGCAGCGAAAATCCTCATATACCGTCAGCAAAACTAAGAGGGCTAAAGGATTGCTACAAAATTA
AACTACGTGCATCGGGATTTCGTCTGGTTTATCAGGTGATTGACGATATGTTAATTATTGCGGTTGTTGCGGTAGGAAAA
CGAGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9211.41 Da Isoelectric Point: 4.0780
>AT37439 WP_001132900.1 NZ_AP023307:c53447-53196 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSNQPLHDVDLD
SYL
Download Length: 252 bp
>AT37439 NZ_AP023307:c53447-53196 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTACCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCTGAACTGTATGAAAGGATGC
TTGATGCTCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTAGAC
AGTTATTTATGA
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTACCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCTGAACTGTATGAAAGGATGC
TTGATGCTCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTAGAC
AGTTATTTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829CDZ2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | V0VIP2 |