Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4189509..4190025 Replicon chromosome
Accession NZ_AP023306
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4567

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag K5646_RS20385 Protein ID WP_000220578.1
Coordinates 4189509..4189793 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag K5646_RS20390 Protein ID WP_000212724.1
Coordinates 4189783..4190025 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5646_RS20370 (4184721) 4184721..4186373 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
K5646_RS20375 (4186782) 4186782..4188920 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
K5646_RS20380 (4189041) 4189041..4189505 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K5646_RS20385 (4189509) 4189509..4189793 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K5646_RS20390 (4189783) 4189783..4190025 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K5646_RS20395 (4190103) 4190103..4192016 - 1914 WP_001212137.1 BglG family transcription antiterminator -
K5646_RS20400 (4192033) 4192033..4192773 - 741 WP_000779263.1 KDGP aldolase family protein -
K5646_RS20405 (4192770) 4192770..4193888 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
K5646_RS20410 (4193872) 4193872..4195005 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T37435 WP_000220578.1 NZ_AP023306:c4189793-4189509 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T37435 NZ_AP023306:c4189793-4189509 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT37435 WP_000212724.1 NZ_AP023306:c4190025-4189783 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT37435 NZ_AP023306:c4190025-4189783 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References