Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3476334..3476954 Replicon chromosome
Accession NZ_AP023306
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4567

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag K5646_RS17120 Protein ID WP_001280991.1
Coordinates 3476736..3476954 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag K5646_RS17115 Protein ID WP_000344807.1
Coordinates 3476334..3476708 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5646_RS17105 (3471473) 3471473..3472666 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K5646_RS17110 (3472689) 3472689..3475838 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
K5646_RS17115 (3476334) 3476334..3476708 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
K5646_RS17120 (3476736) 3476736..3476954 + 219 WP_001280991.1 HHA domain-containing protein Toxin
K5646_RS17125 (3477133) 3477133..3477684 + 552 WP_001278792.1 maltose O-acetyltransferase -
K5646_RS17130 (3477801) 3477801..3478271 + 471 WP_000136181.1 YlaC family protein -
K5646_RS17135 (3478327) 3478327..3478467 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
K5646_RS17140 (3478473) 3478473..3478733 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
K5646_RS17145 (3478958) 3478958..3480508 + 1551 WP_000213139.1 EAL domain-containing protein -
K5646_RS17155 (3480739) 3480739..3481128 + 390 WP_000961285.1 MGMT family protein -
K5646_RS17160 (3481161) 3481161..3481730 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T37430 WP_001280991.1 NZ_AP023306:3476736-3476954 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T37430 NZ_AP023306:3476736-3476954 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT37430 WP_000344807.1 NZ_AP023306:3476334-3476708 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT37430 NZ_AP023306:3476334-3476708 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References