Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3476334..3476954 | Replicon | chromosome |
Accession | NZ_AP023306 | ||
Organism | Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4567 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | V1H8E6 |
Locus tag | K5646_RS17120 | Protein ID | WP_001280991.1 |
Coordinates | 3476736..3476954 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | V1H4V6 |
Locus tag | K5646_RS17115 | Protein ID | WP_000344807.1 |
Coordinates | 3476334..3476708 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K5646_RS17105 (3471473) | 3471473..3472666 | + | 1194 | WP_001039202.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
K5646_RS17110 (3472689) | 3472689..3475838 | + | 3150 | WP_001132508.1 | efflux RND transporter permease AcrB | - |
K5646_RS17115 (3476334) | 3476334..3476708 | + | 375 | WP_000344807.1 | Hha toxicity modulator TomB | Antitoxin |
K5646_RS17120 (3476736) | 3476736..3476954 | + | 219 | WP_001280991.1 | HHA domain-containing protein | Toxin |
K5646_RS17125 (3477133) | 3477133..3477684 | + | 552 | WP_001278792.1 | maltose O-acetyltransferase | - |
K5646_RS17130 (3477801) | 3477801..3478271 | + | 471 | WP_000136181.1 | YlaC family protein | - |
K5646_RS17135 (3478327) | 3478327..3478467 | - | 141 | WP_001197749.1 | type B 50S ribosomal protein L36 | - |
K5646_RS17140 (3478473) | 3478473..3478733 | - | 261 | WP_000801415.1 | type B 50S ribosomal protein L31 | - |
K5646_RS17145 (3478958) | 3478958..3480508 | + | 1551 | WP_000213139.1 | EAL domain-containing protein | - |
K5646_RS17155 (3480739) | 3480739..3481128 | + | 390 | WP_000961285.1 | MGMT family protein | - |
K5646_RS17160 (3481161) | 3481161..3481730 | - | 570 | WP_000779803.1 | YbaY family lipoprotein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8613.97 Da Isoelectric Point: 8.9008
>T37430 WP_001280991.1 NZ_AP023306:3476736-3476954 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
>T37430 NZ_AP023306:3476736-3476954 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14453.27 Da Isoelectric Point: 5.1444
>AT37430 WP_000344807.1 NZ_AP023306:3476334-3476708 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
Download Length: 375 bp
>AT37430 NZ_AP023306:3476334-3476708 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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