Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4462104..4462885 Replicon chromosome
Accession NZ_AP023304
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4551

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag K5676_RS21905 Protein ID WP_000626099.1
Coordinates 4462104..4462595 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag K5676_RS21910 Protein ID WP_001110452.1
Coordinates 4462592..4462885 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5676_RS21865 (4457290) 4457290..4457532 - 243 WP_197603740.1 hypothetical protein -
K5676_RS21870 (4457529) 4457529..4457885 - 357 WP_033567083.1 hypothetical protein -
K5676_RS21875 (4457882) 4457882..4458754 - 873 WP_033567082.1 ParA family protein -
K5676_RS21880 (4458945) 4458945..4459022 - 78 Protein_4295 helix-turn-helix domain-containing protein -
K5676_RS21885 (4459113) 4459113..4459445 - 333 WP_001165471.1 MerR family transcriptional regulator -
K5676_RS21890 (4459517) 4459517..4459894 + 378 WP_000916345.1 EthD family reductase -
K5676_RS21895 (4460927) 4460927..4461001 + 75 Protein_4298 porin family protein -
K5676_RS21900 (4461104) 4461104..4461856 + 753 WP_000842434.1 non-specific acid phosphatase -
K5676_RS21905 (4462104) 4462104..4462595 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
K5676_RS21910 (4462592) 4462592..4462885 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
K5676_RS21915 (4463202) 4463202..4463423 + 222 WP_001576552.1 hypothetical protein -
K5676_RS21920 (4463688) 4463688..4464563 + 876 WP_000921674.1 AraC family transcriptional regulator -
K5676_RS21925 (4464560) 4464560..4464847 + 288 WP_001269916.1 transcriptional regulator RtsB -
K5676_RS21930 (4464870) 4464870..4465085 + 216 WP_001595136.1 hypothetical protein -
K5676_RS21935 (4465093) 4465093..4465362 + 270 WP_010989096.1 hypothetical protein -
K5676_RS21940 (4465656) 4465656..4466561 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T37411 WP_000626099.1 NZ_AP023304:c4462595-4462104 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T37411 NZ_AP023304:c4462595-4462104 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT37411 WP_001110452.1 NZ_AP023304:c4462885-4462592 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT37411 NZ_AP023304:c4462885-4462592 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References