Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 871743..872403 Replicon chromosome
Accession NZ_AP023304
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4551

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag K5676_RS04240 Protein ID WP_000244756.1
Coordinates 871990..872403 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag K5676_RS04235 Protein ID WP_000351186.1
Coordinates 871743..872009 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5676_RS04215 (867671) 867671..869104 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
K5676_RS04220 (869263) 869263..869574 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
K5676_RS04225 (869738) 869738..870397 + 660 WP_000250289.1 hemolysin III family protein -
K5676_RS04230 (870513) 870513..871493 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
K5676_RS04235 (871743) 871743..872009 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
K5676_RS04240 (871990) 871990..872403 + 414 WP_000244756.1 protein YgfX Toxin
K5676_RS04245 (872456) 872456..872977 - 522 WP_001055885.1 flavodoxin FldB -
K5676_RS04250 (873090) 873090..873986 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
K5676_RS04255 (874010) 874010..874723 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K5676_RS04260 (874729) 874729..876462 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T37393 WP_000244756.1 NZ_AP023304:871990-872403 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T37393 NZ_AP023304:871990-872403 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT37393 WP_000351186.1 NZ_AP023304:871743-872009 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT37393 NZ_AP023304:871743-872009 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References