Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 870406..871066 Replicon chromosome
Accession NZ_AP023303
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4526

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag K5618_RS04230 Protein ID WP_000244756.1
Coordinates 870653..871066 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag K5618_RS04225 Protein ID WP_000351186.1
Coordinates 870406..870672 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5618_RS04205 (866334) 866334..867767 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
K5618_RS04210 (867926) 867926..868237 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
K5618_RS04215 (868401) 868401..869060 + 660 WP_000250289.1 hemolysin III family protein -
K5618_RS04220 (869176) 869176..870156 - 981 WP_000874172.1 tRNA-modifying protein YgfZ -
K5618_RS04225 (870406) 870406..870672 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
K5618_RS04230 (870653) 870653..871066 + 414 WP_000244756.1 protein YgfX Toxin
K5618_RS04235 (871119) 871119..871640 - 522 WP_001055885.1 flavodoxin FldB -
K5618_RS04240 (871753) 871753..872649 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
K5618_RS04245 (872673) 872673..873386 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K5618_RS04250 (873392) 873392..875125 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T37370 WP_000244756.1 NZ_AP023303:870653-871066 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T37370 NZ_AP023303:870653-871066 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT37370 WP_000351186.1 NZ_AP023303:870406-870672 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT37370 NZ_AP023303:870406-870672 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References