37363

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 63549..64192 Replicon plasmid L-4445 strain 4[5]12:i:-
Accession NZ_AP023301
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4445

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag K5630_RS24255 Protein ID WP_001044768.1
Coordinates 63549..63965 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag K5630_RS24260 Protein ID WP_001261287.1
Coordinates 63962..64192 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5630_RS24240 (58853) 58853..59746 - 894 WP_001553853.1 S-4TM family putative pore-forming effector -
K5630_RS24245 (59789) 59789..60784 - 996 WP_000246636.1 hypothetical protein -
K5630_RS24250 (61249) 61249..63387 + 2139 WP_039002805.1 AAA family ATPase -
K5630_RS24255 (63549) 63549..63965 - 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
K5630_RS24260 (63962) 63962..64192 - 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K5630_RS24905 (64498) 64498..65046 + 549 WP_039002808.1 hypothetical protein -
K5630_RS24910 (65098) 65098..65928 + 831 WP_223201786.1 hypothetical protein -
K5630_RS24915 (65979) 65979..67616 + 1638 WP_223201785.1 hypothetical protein -
K5630_RS24270 (67879) 67879..69012 + 1134 WP_000545983.1 DUF3800 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mcr-3.1 / aac(3)-IId / blaTEM-1B / sul3 / tet(A) / sul2 / floR / dfrA12 / aadA2 / cmlA1 / ant(3'')-Ia / tet(M) - 1..131843 131843


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T37363 WP_001044768.1 NZ_AP023301:c63965-63549 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

>T37363 NZ_AP023301:c63965-63549 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT37363 WP_001261287.1 NZ_AP023301:c64192-63962 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT37363 NZ_AP023301:c64192-63962 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References