Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4399589..4400370 Replicon chromosome
Accession NZ_AP023300
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4445

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag K5630_RS21490 Protein ID WP_000626099.1
Coordinates 4399589..4400080 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag K5630_RS21495 Protein ID WP_001110452.1
Coordinates 4400077..4400370 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5630_RS21450 (4394775) 4394775..4395017 - 243 WP_197603740.1 hypothetical protein -
K5630_RS21455 (4395014) 4395014..4395370 - 357 WP_033567083.1 hypothetical protein -
K5630_RS21460 (4395367) 4395367..4396239 - 873 WP_033567082.1 ParA family protein -
K5630_RS21465 (4396430) 4396430..4396507 - 78 Protein_4217 helix-turn-helix domain-containing protein -
K5630_RS21470 (4396598) 4396598..4396930 - 333 WP_001165471.1 MerR family transcriptional regulator -
K5630_RS21475 (4397002) 4397002..4397379 + 378 WP_000916345.1 EthD family reductase -
K5630_RS21480 (4398412) 4398412..4398486 + 75 Protein_4220 porin family protein -
K5630_RS21485 (4398589) 4398589..4399341 + 753 WP_000842434.1 non-specific acid phosphatase -
K5630_RS21490 (4399589) 4399589..4400080 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
K5630_RS21495 (4400077) 4400077..4400370 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
K5630_RS21500 (4400687) 4400687..4400908 + 222 WP_001576552.1 hypothetical protein -
K5630_RS21505 (4401173) 4401173..4402048 + 876 WP_000921674.1 AraC family transcriptional regulator -
K5630_RS21510 (4402045) 4402045..4402332 + 288 WP_001269916.1 transcriptional regulator RtsB -
K5630_RS21515 (4402355) 4402355..4402570 + 216 WP_001595136.1 hypothetical protein -
K5630_RS21520 (4402578) 4402578..4402847 + 270 WP_010989096.1 hypothetical protein -
K5630_RS21525 (4403141) 4403141..4404046 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T37359 WP_000626099.1 NZ_AP023300:c4400080-4399589 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T37359 NZ_AP023300:c4400080-4399589 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT37359 WP_001110452.1 NZ_AP023300:c4400370-4400077 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT37359 NZ_AP023300:c4400370-4400077 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References