Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3476335..3476955 Replicon chromosome
Accession NZ_AP023300
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4445

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag K5630_RS17120 Protein ID WP_001280991.1
Coordinates 3476737..3476955 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag K5630_RS17115 Protein ID WP_000344807.1
Coordinates 3476335..3476709 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5630_RS17105 (3471474) 3471474..3472667 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K5630_RS17110 (3472690) 3472690..3475839 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
K5630_RS17115 (3476335) 3476335..3476709 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
K5630_RS17120 (3476737) 3476737..3476955 + 219 WP_001280991.1 HHA domain-containing protein Toxin
K5630_RS17125 (3477134) 3477134..3477685 + 552 WP_001278792.1 maltose O-acetyltransferase -
K5630_RS17130 (3477802) 3477802..3478272 + 471 WP_000136181.1 YlaC family protein -
K5630_RS17135 (3478328) 3478328..3478468 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
K5630_RS17140 (3478474) 3478474..3478734 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
K5630_RS17145 (3478959) 3478959..3480509 + 1551 WP_000213139.1 EAL domain-containing protein -
K5630_RS17155 (3480740) 3480740..3481129 + 390 WP_000961285.1 MGMT family protein -
K5630_RS17160 (3481162) 3481162..3481731 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T37353 WP_001280991.1 NZ_AP023300:3476737-3476955 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T37353 NZ_AP023300:3476737-3476955 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT37353 WP_000344807.1 NZ_AP023300:3476335-3476709 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT37353 NZ_AP023300:3476335-3476709 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References