Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4189536..4190052 Replicon chromosome
Accession NZ_AP023299
Organism Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4334

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag K5616_RS20385 Protein ID WP_000220578.1
Coordinates 4189536..4189820 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag K5616_RS20390 Protein ID WP_000212724.1
Coordinates 4189810..4190052 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5616_RS20370 (4184748) 4184748..4186400 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
K5616_RS20375 (4186809) 4186809..4188947 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
K5616_RS20380 (4189068) 4189068..4189532 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K5616_RS20385 (4189536) 4189536..4189820 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K5616_RS20390 (4189810) 4189810..4190052 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K5616_RS20395 (4190130) 4190130..4192043 - 1914 WP_001212137.1 BglG family transcription antiterminator -
K5616_RS20400 (4192060) 4192060..4192800 - 741 WP_000779263.1 KDGP aldolase family protein -
K5616_RS20405 (4192797) 4192797..4193915 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
K5616_RS20410 (4193899) 4193899..4195032 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T37334 WP_000220578.1 NZ_AP023299:c4189820-4189536 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T37334 NZ_AP023299:c4189820-4189536 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT37334 WP_000212724.1 NZ_AP023299:c4190052-4189810 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT37334 NZ_AP023299:c4190052-4189810 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References