Detailed information of TA system TA037313

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 1871..2430
• Replicon: plasmid L-4261 strain 4[5]12:i:-
• Accession: NZ_AP023295
• Organism: Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain L-4261

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A7ZGU0
• Locus tag: K5635_RS23905
• Protein ID: WP_012000729.1
• Coordinates: 2155..2430 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8D4Z751
• Locus tag: K5635_RS23900
• Protein ID: WP_053264211.1
• Coordinates: 1871..2155 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5635_RS23890 (34)	34..108	+	75	WP_001365705.1	RepA leader peptide Tap	-
K5635_RS23895 (101)	101..958	+	858	WP_021579013.1	incFII family plasmid replication initiator RepA	-
K5635_RS23900 (1871)	1871..2155	+	285	WP_053264211.1	ribbon-helix-helix domain-containing protein	Antitoxin
K5635_RS23905 (2155)	2155..2430	+	276	WP_012000729.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K5635_RS23910 (2584)	2584..3588	+	1005	WP_074568613.1	hypothetical protein	-
K5635_RS23915 (3685)	3685..4689	-	1005	WP_244582493.1	hypothetical protein	-
K5635_RS23920 (4873)	4873..5268	-	396	WP_053265925.1	plasmid partitioning/stability family protein	-
K5635_RS23925 (5268)	5268..6227	-	960	WP_000921959.1	plasmid segregation protein ParM	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..60222	60222

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (14-51)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10695.40 Da
• Isoelectric Point: 9.9324

>T37313 WP_012000729.1 NZ_AP023295:2155-2430 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELTGQTVY
VLRLWHTRESR

Nucleotide

• Length: 276 bp

>T37313 NZ_AP023295:2155-2430 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGCACCAGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCAGGTGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTGTCTAT
GTATTGCGCTTGTGGCATACGCGGGAAAGCAGATAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10516.97 Da
• Isoelectric Point: 5.6558

>AT37313 WP_053264211.1 NZ_AP023295:1871-2155 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQVVQAW
ADSLSTDNPLPVPR

Nucleotide

• Length: 285 bp

>AT37313 NZ_AP023295:1871-2155 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTAATTACTGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGATTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGTTGTACAGGCCTGG
GCGGACAGTCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Structures

Toxin

• AlphaFold DB: A7ZGU0